Chronic myelogenous leukemia is characterized by a specific chromo somal translocation, t(9;22), in which the ABL protooncogene and the BCR gene become juxtaposed. The chlmenc BCR/ABL gene produces a P210 fusion protein with deregulated tyrosine kinase activity. We have recently isolated a complementary DNA, CRKL, which could code for an adaptor protein consisting of one SH2 and two SH3 domains...

INTRODUCTION..................................................................................................... 1325 I. CONTRACTING AT THE IPO STAGE ................................................................. 1331 A. IPO Charters and Takeover Defenses ...................................................... 1332 B. Innovation, Diversity, and the “Plain Vanilla” Charter ......................

1. Woywodt A, Haubitz M, Haller H, Matteson EL: Wegener’s granulomatosis. Lancet 367: 1362–1366, 2006 2. Klinger H: Grenzformen der Periarteriitis Nodosa. Frankf Z Pathol 42: 455–480, 1931 3. Wegener F: Ueber generalisierte septische Gefäßerkrankungen. Verh Deut Pathol Ges 29: 202–210, 1936 4. Wegener F: Ueber eine eigenartige rhinogene Granulomatose mit besonderer Beteiligung des Arteriensyste...

Wright, Elizabeth A. (University of Kentucky College of Medicine, Lexington), and David C. White. Formation of a functional electron transport system during growth of penicillin-induced spheroplasts of Haemophilus parainfluenzae. J. Bacteriol. 91:1356-1362. 1966.-Penicillin in a lactose medium can be used to cause the formation of spheroplasts in Haemophilus parainfluenzae. The resulting sphero...

The Earth Radiation Budget at the top of the atmosphere quantifies how the Earth gains energy from the Sun and loses energy to space. It is of fundamental importance for climate and climate change. In this paper, the current state-of-the-art of the satellite measurements of the Earth Radiation Budget is reviewed. Combining all available measurements, the most likely value of the Total Solar Irr...

Transformation-associated recombination (TAR) in yeast is a rapid and inexpensive method for cloning and assembly of large DNA fragments, which relies on natural homologous recombination. Two vectors, based on p15a and F-factor replicons that can be maintained in yeast, E. coli and streptomycetes have been constructed. These vectors have been successfully employed for assembly of the grecocycli...