background: chlorotoxin is a 36-amino acid peptide found in the venom of the leiurus quinquestriatus which blocks small-conductance chloride channels. chlorotoxin binds preferentially to glioma cells that allow development of new methods for the treatment and diagnosis of several types of cancer. thus chlorotoxin derivative was labeled with 131i for further investigation. materials and methods:...

Objective(s): High-risk neuroblastoma is a childhood cancer with poorprognosis despite modern multimodality therapy. Internal radiotherapy using131I-metaiodobenzylguanidine (MIBG) is effective for treating the disease even if it isresistant to chemotherapy. The aim of this study is to evaluate the safety and efficacyof 131I-MIBG radiotherapy combined with myeloablative high-dose chemotherapyand...

introduction: radioiodine (131i) is an effective and inexpensive alternative to surgery in the treatment of thyroid hyperfunction. the debate today concerns the maximum and minimum ablative doses, and factors leading to hypothyroidism. patients & method: 1035 hyperthyroid patients treated with weight-adjusted ablative doses of 131i were retrospectively assessed for treatment outcome or corr...

Glioblastoma (GBM) is the most common and most aggressive primary brain tumor; the prognosis of patients with GBM remains poor. The sodium/iodide symporter (NIS) can be used to absorb several isotopes, such as 131I for nuclear medicine imaging and radionuclide therapy. Previously, we found that the early growth response-1 (Egr1) promoter had an 131I radiation positive feedback effect on the NIS...

BACKGROUND In the most patients with differentiated thyroid carcinoma (DTC), recurrent disease occurs in the neck region, but the usefulness of neck ultrasound (US) in its diagnosis is not clear. The aim of this study was to evaluate the significance of US in the detection of neck recurrence in low-risk DTC patients at first follow-up visits. MATERIAL AND METHODS A total of 32 patients, who h...

Specific molecular probes are essential for the early diagnosis of prostate cancer. In addition, peptides have been shown to have numerous uses as diagnostic and therapeutic molecular probes. The K237 peptide binds to the vascular endothelial growth factor receptor with high affinity and specificity, and was predicted to have potential use as a probe in tumor angiogenesis. The overall aim of th...

UNLABELLED The aim of the present study was to assess whether 131I therapy for differentiated thyroid carcinoma (DTC) can affect endocrine testicular function. METHODS Serum follicle-stimulating hormone (FSH) and testosterone (T) concentrations were measured in 103 patients periodically submitted for radioiodine therapy for residual or metastatic disease. Mean follow-up was 93.7 +/- 54 mo (ra...

Breast tumors are susceptible to attack by unconjugated anti-human milk fat globule monoclonal antibodies (MoAbs) and most particularly by their mixture (cocktail) (Cancer Res., 47: 532-540, 1987). In the present study the same MoAbs (Mc1, Mc3, Mc5, and Mc8) labeled with 131I, either singly or in cocktails, were used for a similar purpose. Biodistribution studies showed that a transplantable hu...

ADRENAL-SPECIFIC RADIOLIGAND, 131I-6β-iodomethyl-19norcholest-5(10)-en-3β-ol (131I-adosterol)1 was developed in the 1970s. Increased uptake of the agent in tumor regardless of visualization of the contralateral gland suggests that the adrenal mass is usually a benign cortical adenoma.2 This agent has the potency to diagnose lesions of the adrenal cortex and has been widely used to diagnose lesi...

Clinical trials of radioimmunotherapy (RIT) of lymphoma have produced frequent tumor regressions and remissions, but it has been difficult to determine to what extent these tumor responses have been due to antibody-specific targeted radiation, nontargeted radiation, and/or cytotoxicity mediated by the carrier monoclonal antibody (MoAb). In this report, RIT was studied in athymic nude mice beari...