Despite strong evidence for an association between the experience of posttraumatic stress (PTS) symptoms and substance use, little is known about the particular individuals most at-risk for problematic substance use in response to PTS symptoms. Consequently, the goal of this study was to conduct a prospective investigation of the moderating role of emotion dysregulation (assessed through self-r...

PTS 516. Clinical Research I. 3 Credit Hours. Principles, concepts, and basic skills required to conduct clinical research in physical therapy. Topics include research design, sampling, bias, reliability and validity, questionnaire design, statistical computing, conceptual review of literature, and the preparation of a research proposal. Requisite: Physical Therapy Majors Only. Components: LEC....

PTS 516. Clinical Research I. 3 Credit Hours. Principles, concepts, and basic skills required to conduct clinical research in physical therapy. Topics include research design, sampling, bias, reliability and validity, questionnaire design, statistical computing, conceptual review of literature, and the preparation of a research proposal. Requisite: Physical Therapy Majors Only. Components: LEC....

Retifanlimab (INCMGA00012) is a humanized monoclonal antibody targeting programmed death protein-1 (PD-1). INCB001158 potent, highly selective arginase inhibitor that may improve anti-tumor immune responses. For patients (pts) who relapse or develop resistance to anti-PD-1 agents, combination therapy be an option. POD1UM-104 (NCT03910530) phase 1b, open-label, multicenter study evaluate safety ...

OBJECTIVE To develop and validate a predictive score for clinical complications during intra-hospital transport of infants treated in neonatal units. METHODS This was a cross-sectional study nested in a prospective cohort of infants transported within a public university hospital from January 2001 to December 2008. Transports during even (n=301) and odd (n = 394) years were compared to develo...

BACKGROUND Postthrombotic syndrome (PTS) is a frequent chronic complication of deep venous thrombosis, yet its impact on health-related quality of life has not been well characterized. We compared generic and venous disease-specific quality of life in patients with and without PTS, and assessed whether quality of life correlated with severity of PTS. METHODS Subjects with previous deep venous...

Results Fifty HIV+/HCV+ coinfected pts (n=44 men (88%), median age 50 years [40-74], median CD4 cell count 334/mm3 [58-1621], n=28 Child A cirrhosis (60%)) developed HCC. Thirty-one (63%) pts presented cirrhosis decompensation before HCC diagnosis. At HCC diagnosis, median serum aFP was 20.4 [1.9-198,900] ng/ml, 38 (76%) pts had a nodular tumor (median main diameter 23.5 [11-70] cm) and 12 (24%...

gency room. Sixty pts were on mechanical ventilatory support. Passage of the scope was difficult in 2 pts. Nine developed transient hypoxemia, one requiring mechanical ventilation. Findings: 116 pts (82%) had no evidence of aortic trauma on TEE. Aortic disruption was noted in 6 pts (4%). 5 of whom underwent surgery and survived. In 15 pts the findings were indeterminate. Aortogram in these pts ...

Sucrose is one of the most promising carbon sources for industrial fermentation. We expressed synthetic modules expressing genes of the PEP-PTS and non-PTS pathways in Escherichia coli K12 for comparison. We selected PEP-PTS pathway genes of Lactobacillus plantarum and Staphylococcus xylosus and non-PTS pathway genes of sucrose-utilizing (Scr(+)) E. coli EC3132. Switchable Scr(+) modules expres...

BACKGROUND In Escherichia coli phosphoenolpyruvate (PEP) is a key central metabolism intermediate that participates in glucose transport, as precursor in several biosynthetic pathways and it is involved in allosteric regulation of glycolytic enzymes. In this work we generated W3110 derivative strains that lack the main PEP consumers PEP:sugar phosphotransferase system (PTS-) and pyruvate kinase...