Febrile illness-related epilepsy syndrome is a catastrophic epileptic encephalopathy that is highly refractory to most antiepileptic drugs leading to high morbidity and mortality. The authors report the use of a pediatric infusion protocol of continuous intravenous magnesium sulfate for the control of seizures in 2 children with febrile illness-related epilepsy syndrome refractory to multiple a...

Practice Pointers Preterm birth, defined as occurring before 37 weeks of gestation, is the leading cause of neonatal death and is associated with several shortand long-term infant morbidities. Tocolytics, agents that inhibit uterine contractions, are commonly used to prevent or delay preterm birth. Magnesium sulfate is one of the most commonly used tocolytics in the United States.1 An earlier p...

BACKGROUND Eclampsia is the main cause of maternal death in Brazil. Magnesium sulfate is the drug of choice for seizure prevention and control in the management of severe preeclampsia and eclampsia. Despite scientific evidence demonstrating its effectiveness and safety, there have been delays in managing hypertensive disorders, including timely access to magnesium sulfate. To conduct a general ...

Clinical studies showed beneficial effects of magnesium sulfate regarding the risk of cerebral palsy. However, regimen protocols fluctuate worldwide and risks of adverse effects impacting the vascular system have been reported for human neonates, keeping open the question of the optimal dosing. Using clinically relevant concentrations and doses of magnesium sulfate, experiments consisted of cha...

BACKGROUND Rest cramps (also known as nocturnal leg cramps) are very common in a geriatric population. Oral magnesium supplements are marketed for prophylaxis of such cramps but clinical trials exploring the efficacy of oral magnesium conflict. A therapeutic trial of intravenous magnesium overcomes the limited oral bioavailability of magnesium and better assesses its therapeutic potential. ME...

though intravenous (iv) magnesium sulphate (mgs04) has additive effect to beta-2 agonists, its additive benefit in face of combination therapy with beta-2-agonists and ipratropium (standard therapy of severe acute exacerbation of asthma) remains unaddressed. the aim of this investigation was to evaluate the role of iv mgso4 when used as an adjunct to standard therapy of severe exacerbations of ...

background new drugs are increasingly used to induce analgesia during surgeries. this study compared the analgesic effects of paracetamol and magnesium sulfate. methods sixty patients with american society of anesthesiologists (asa) class i or ii patients who were candidates for surgery of the lower limbs were randomly divided into three equal groups who were age and gender matched. group 1 rec...