The Ca2+/calmodulin-dependent protein kinase (CaMK) type IV/Gr is selectively expressed in T lymphocytes and is activated after signaling via the T cell antigen receptor (TCR), indicating that it mediates some of the Ca(2+)-dependent transcriptional events that follow TCR engagement. Here we show that CaMKIV/Gr induces the transcription factor activation protein 1 (AP-1) alone or in synergy wit...

Alcohol is a potential risk factor of type 2 diabetes, but its underlying mechanism is unclear. To explore this issue, Wistar rats and mouse hepatoma cells (Hepa 1-6) were exposed to ethanol, 8 g·kg(-1) ·d(-1) for 3 months and 100 mM for 48 h, respectively. Glucose and insulin tolerance tests in vivo were performed, and protein levels of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) and gl...

Glucocorticoid stress hormones (GCs) are well known for being anti-inflammatory, but some reports suggest that GCs can also augment aspects of inflammation during acute brain injury. Because the GC receptor (GR) is ubiquitously expressed throughout the brain, it is difficult to know which cell types might mediate these unusual "proinflammatory" GC actions. We examined this with cell type-specif...

The Notch signaling pathway modulates cell fate in diverse contexts, including vascular development. Notch4 is selectively expressed in vascular endothelium and regulates vascular remodeling. The signal-dependent transcription factor activator protein 1 (AP-1) activates Notch4 transcription in endothelial cells, but other factors/signals that regulate Notch4 are largely unknown. We demonstrate ...

The glucocorticoid receptor (GR) mediates the biological effects of glucocorticoids (GCs) through activation or repression of gene expression, either by DNA binding or via interaction with other transcription factors, such as AP-1. Work in tissue culture cells on the regulation of AP-1-dependent genes, such as collagenase (MMP-13) and stromelysin (MMP-3) has suggested that the antitumor and ant...

The ability of the glucocorticoid receptor (GR) to regulate the transcriptional output of genes relies on its interactions with transcriptional coregulators. However, which coregulators are required for GR-dependent activation is context-dependent and can be influenced by the sequence of the DNA bound by GR and by the nature of the GR isoform responsible for the regulation of a gene. Here, we s...

Each Gr-category (or categorical group) is Gr-equivalent to a Grcategory of type (Π, A, ξ), where Π is a group, A is a Π-module and ξ is a 3-cocycle of Π, with coefficients in A. In this paper, first we show that each Gr-functor induces one between Gr-categories of type (Π, C). Then we give results on the existence of Gr-functor and the classification of Gr-functors by cohomology groups H(Π, C)...

Abuse liability of diazepam was examined among experienced drug users. The subjects, randomly divided into two groups, each having eight subjects, received diazepam, 15 mg intravenously (gr. 1) and 30 mg orally (gr. 2). Subjective states, drug liking, sedation and euphoria were assessed at pre-drug, 15 min, 120 min and 240 min post-drug administration. In addition, brief assessment to evaluate ...

In this paper we derive a Gilbert-Varshamov type bound for linear codes over Galois rings. For linear codes over the Galois ring GR(pl; j) the result can be stated as follows. Given r; such that 0 < r < 1 and 0 < H 1 pj (1 r): Then for all n N; where N is a sufficiently large integer, there exist [n; k] GR linear codes over GR(pl; j) such that k=n r and d=n : Consequently, this bound does not g...