Substrates for mitotic proteolysis such as cyclin B have a 9 residue destruction motif, the destruction box (D-box). To identify the receptor that specifically binds the D-box, we used affinity chromatography with immobilized D-box matrices. We find that the APC/C from Xenopus egg extracts binds to the D-box of cyclin B, whereas Fizzy (Cdc20) does not. Mutations in the D-box abolished this inte...

This study aims to develop a learning product in the form of developing media Exploading Box Pop Up 3d Class IV thematic at SD Negeri 76 Lubuklinggau which is valid and practical. type research development (R&D) with model used, namely 4D (define, design, desiminate). The sample or subject class students totaling 16 students. Data collection techniques were carried out through interviews, d...

[1] Several recent papers have demonstrated a decrease in atmospheric pCO2 resulting from barriers to communication between the deep sea and the atmosphere in the Southern Ocean. Stephens and Keeling [2000] decreased pCO2 by increasing Antarctic sea ice in a seven-box model of the world ocean, and Toggweiler [1999] showed a similar response to Southern Ocean stratification. In box models the pC...

Gauge field theory with rank-one $T_{\mu}$ is a quantum that describes the interaction of elementary spin-1 particles, which being massless to preserve gauge symmetry. In this paper, we give generalized, extended study abelian under successive rotor model in general $D$-dimensional flat spacetime for particles context higher order derivatives. We establish theorem $n$ contributes $\Box^n T^{\mu...

Light serves as a key environmental signal for synchronizing the circadian clock with the day night cycle. The zebrafish represents an attractive model for exploring how light influences the vertebrate clock mechanism. Direct illumination of most fish tissues and cell lines induces expression of a broad range of genes including DNA repair, stress response and key clock genes. We have previously...

In our six box model (6BM) the Southern Ocean is represented by an Antarctic and a Subantarctic region. For simplicity, the lower (blue) circulation is represented entirely by mixing between the Antarctic surface waters (box a) and the deep ocean (box d), Mixad. The upper (red) circulation is represented by upwelling in the Subantarctic region (box s) and the subsequent transport of water to th...

Cite this article: Jessop M, Riggs D, Jackson B, Zaslau S (2017) Stress Related Induction of Bladder Urothelial Changes in Mice: A New Murine Model. J Genitourin Disord 1(1): 1003. *Corresponding author Stanley Zaslau, Section of Urology, Department of Surgery, Robert C. Byrd Health Science center, West Virginia University, Morgantown, PO Box 9238, USA, Tel: 304-293-1105; Fax: 304-293-2807; Ema...

The anaphase-promoting complex/cyclosome (APC/C) regulates sister chromatid segregation and the exit from mitosis. Selection of most APC/C substrates is controlled by coactivator subunits (either Cdc20 or Cdh1) that interact with substrate destruction motifs--predominantly the destruction (D) box and KEN box degrons. How coactivators recognize D box degrons and how this is inhibited by APC/C re...

Models of the mammalian clock have traditionally been based around two feedback loops-the self-repression of Per/Cry by interfering with activation by BMAL/CLOCK, and the repression of Bmal/Clock by the REV-ERB proteins. Recent experimental evidence suggests that the D-box, a transcription factor binding site associated with daytime expression, plays a larger role in clock function than has pre...

Most small nucleolar RNAs (snoRNAs) fall into two families, known as the box C/D and box H/ACA snoRNAs. The various box elements are essential for snoRNA production and for snoRNA-directed modification of rRNA nucleotides. In the case of the box C/D snoRNAs, boxes C and D and an adjoining stem form a vital structure, known as the box C/D motif. Here, we examined expression of natural and artifi...