evidence acquisition elevated serum leptin levels are regarded as an established marker of obesity. it is also reported that obese asthmatic patients have maximum serum leptin levels compared to other groups such as non-obese asthmatics, and normal obese and non obese subjects without asthma. in addition to having an appetite suppressing effect, leptin also regulates certain acute-phase protein...

OBJECTIVE To describe trends of reported alpha 1-antitrypsin deficiency mortality in the United States from 1979-1991. METHODS We analyzed death certificate reports in the multiple-cause mortality files compiled by the National Center for Health Statistics. RESULTS Of the 26,866,600 deaths that occurred during the 13-year period, 1,930 had alpha 1-antitrypsin deficiency listed as a cause of...

Alpha-1 antitrypsin deficiency is known as a significant genetic risk factor for COPD for carriers of phenotype PIMZ, and for phenotypes PIZZ and PISZ. Genetic epidemiological studies for alpha-1 antitrypsin deficiency conducted by others on both COPD patients and concurrent non-COPD controls were used to estimate the risk factors for all six phenotypic classes (namely, the normal phenotype PIM...

Maternal serum alpha 1-antitrypsin concentrations were measured serially in pregnant women who were normotensive and those with mild, moderate, and severe hypertension of pregnancy from 27 weeks' gestation to term. alpha 1-antitrypsin concentrations increased with advancing gestation in all four groups. In addition, the hypertensive pregnancies showed higher than normal concentrations at each s...

www.thelancet.com Published online May 28, 2015 http://dx.doi.org/10.1016/S0140-6736(15)60036-8 1 α1 antitrypsin is a serine antiprotease secreted by the liver. Its main function is inhibition of neutrophil elastase, a non-specifi c protease released by activated or dying neutrophils. In individuals with healthy concentrations of α1 antitrypsin, the fragile alveolar structures of the lung paren...

The serum alpha-1 antitrypsin level was measured in 60 patients with endogenous uveitis, 27 patients with phacoallergic endophthalmitis, 12 patients with phacolytic glaucoma, and 58 healthy subjects. Thirty-four patients with endogenous uveitis were also followed up for 6 months after treatment, and the serum alpha-1 antitrypsin level was measured again. There was a significant rise in the seru...

alpha 1 antitrypsin is an important immunoregulatory protein, the serum level of which is genetically determined. Deficient phenotypes of this ubiquitous protease inhibitor are associated with a variety of inflammatory diseases including anterior uveitis. In order to investigate the role of this protease inhibitor in the pathogenesis of retinal vasculitis (RV) 25 patients were investigated. Dis...