Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) results in a broad spectrum of toxic effects. Most, if not all, of these responses are dependent upon the binding of dioxin to the aryl hydrocarbon receptor. Given their common roles in chemically induced toxicity, we asked whether interleukin 1 (IL1)-like cytokines play a role in acute aspects of the dioxin response. To test this idea, w...

1. A genetic risk-association study involving more than 1200 subjects showed individuals homozygous for L-SIGN tandem repeats are less susceptible to SARS infection. 2. This was supported by in vitro binding studies that demonstrated homozygous L-SIGN, compared to heterozygous, had higher binding capacity for SARS coronavirus (SARS-CoV), with higher proteasome-dependent viral degradation. In co...

The mechanism of the lymphoproliferative effect of the macrophage product lymphocyte-activating factor [LAF(IL1] appears to be mediated by the stimulation of the release of T cell growth factor [TCGF(IL2)] by T cells. The magnitude of the resultant T cell proliferative clonal expansion is thus dependent upon the quantity of both LAF(IL1) and TCGF(IL2) induced by antigen or lectin stimulation. T...

Abstract IL1? is a central mediator of inflammation. Secretion typically requires proteolytic maturation by the inflammasome and formation membrane pores gasdermin D (GSDMD). Emerging evidence suggests an important role for in promoting cancer progression patients, but underlying mechanisms are ill-defined. Here, we have shown key driving tumor two distinct mouse models. Notably, activation inf...

Background: Vitiligo is a hypomelanotic autoimmune skin disorder arising from a breakdown in immunological self-tolerance, which leads to aberrant immune responses against melanocytes leading to selective destruction of melanocytes. High levels of Interleukin 1(IL1) have been reported in various autoimmune disorders including vitiligo. The aim of present study was to explore the effect of IL1-α...

Damaged dental pulp undergoes oxidative stress and 4-hexylresorcinol (4HR) is a well-known antioxidant. In this study, we aimed to evaluate the therapeutic effects of 4HR ointment on damaged pulp. Pulp cells from rat mandibular incisor were cultured treated with or resveratrol (1–100 ?M). These treatments (10–100 ?M) exerted protective effect during subsequent hydrogen peroxide treatments. The ...

interleukin-1β (il-1β) is one of the most important cytokines which seems to have an important role in the inflammatory process in gingival and peri-implant tissues. the aim of this split-mouth study was to investigate the relationship between the concentration of il-1β in gingival crevicular fluid (gcf) and peri-implant crevicular fluid (picf) and clinical parameters such as plaque index (pi),...

Purpose of the study: The goal of this study was to review the recent evidence regarding the pathophysiology of reactive skin, acne vulgaris and rosacea, with a focus on the link between the impaired skin barrier and the inflammasome. In this context, we evaluated the activity of Rhealba oat plantlet extract on the inflammasome in vitro. Procedures: Using an in vitro inflammatory model of Recon...

BACKGROUND We investigated two distinct synovial fibroblast populations that were located preferentially in the lining or sub-lining layers and defined by their expression of either podoplanin (PDPN) or CD248, and explored their ability to undergo self-assembly and transmigration in vivo. METHODS Synovial fibroblasts (SF) were cultured in vitro and phenotypic changes following stimulation wit...