The potential of hepatocyte growth factor (HGF) to regulate the expression of urokinase plasminogen activator (uPA) in a gastric cancer cell is not widely acknowledged. To identify the genes associated with the plasminogen activator proteolytic axis by HGF, we used cDNA microarray technology and selected genes upregulated or downregulated in two gastric cell lines (NUGC-3 and MKN-28). First, IL...

In exaggerated pain states, the activated astrocytes release several signalling molecules involved in cellular mechanisms of chronic pain. Among them, nerve growth factor (NGF) and interleukin (IL)-1β are both recognized as potent algogens. We previously showed that histamine is a potent stimulator of NGF production in rat cortical astrocytes in primary culture. Since histamine and IL-1β have c...

Maternal obesity is a major risk factor for pregnancy complications, causing inflammatory cytokine release in the placenta, including interleukin-1β (IL-1β), IL-6, and IL-8. Pregnant women with obesity develop accelerated systemic and placental inflammation with elevated circulating advanced glycation end products (AGEs). IL-1β is a pivotal inflammatory cytokine associated with obesity and preg...

Dental calculus is a mineralized deposit associated with periodontitis. The bacterial components contained in dental calculus can be recognized by host immune sensors, such as Toll-like receptors (TLRs), and induce transcription of proinflammatory cytokines, such as IL-1β. Studies have shown that cellular uptake of crystalline particles may trigger NLRP3 inflammasome activation, leading to the ...

BACKGROUND Interleukin-1β (IL-1β), the major cytokine involved in activation of hypothalamic-pituitary-adrenal (HPA) axis modulates both central and peripheral components regulating HPA activity. The role of nitric oxide (NO) generated by neuronal nitric oxide synthase (nNOS) and inducible nitric oxide synthase (iNOS) in brain structures involved in HPA axis regulation has not been elucidated. ...

Background: Pre-eclampsia is the most common critical condition during pregnancy. Plasma concentrations of tumor necrosis factor-alpha (TNF-α) and interleukin-1-beta (IL-1β) increase in pregnant women with pre-eclampsia, compared to normal pregnant women. Objective: To investigate the polymorphisms of IL-1β (C+3954T), TNF-α (G- 308A), and (G-238A) in preeclemptic women northeastern Iran. Me...

Periodontitis is caused by the inflammation of tooth-supporting tissue pathogens such as Aggregatibacter actinomycetemcomitans. Interleukin-1β (IL-1β), a pro-inflammatory cytokine, triggers series inflammatory reactions and promotes bone resorption. The aim this study was to examine molecular mechanism anti-inflammatory function zingerone, dietary phenolic found in Zingiber officinale, on perio...

Abstract Objective In this study, we investigated the levels of interleukin‐1β (IL‐1β), IL‐18, and NOD‐like receptor pyrin domain‐containing 3 (NLRP3) inflammasome in patients with premature rupture membranes (PROMs). Methods We selected 60 pregnant women at Fourth Hospital Baotou between January 2019 July 2021. These were divided into three distinct groups: preterm PROM group 20 cases, term (T...

Exposure to particulate matter (PM) and exercise training can have antagonistic effects on inflammatory responses the balance between pro-oxidants antioxidants in body. However, underlying mechanisms of these remain unclear. This study aimed investigate PM exposure aerobic oxidative stress, antioxidant status, inflammation mice different ages. Two groups male C57BL/6 mice, comprising forty 1-mo...