Several studies indicate that cholesterol esterification is deregulated in cancers. The present study aimed to characterize the role of cholesterol esterification in proliferation and invasion of two tumor cells expressing an activated cholecystokinin 2 receptor (CCK2R). A significant increase in cholesterol esterification and activity of Acyl-CoA:cholesterol acyltransferase (ACAT) was measured...

PURPOSE This study was done to determine the risk factors for recurrent fallers (2+falls) compared to single fallers. METHODS Participants were 104 community-dwelling people 65 yr of age or older. The data were collected from June 1, 2008 to June 30, 2009 using the Residential Assessment Instrument-Home Care. RESULTS Over the past 90 days, 55.7% of the 104 participants fell once, and 44.2% ...

BACKGROUND Antiplatelet therapy with aspirin and antithrombotic therapy with heparin both prevent the complications of unstable angina; however, no definitive data exist on the relative clinical efficacy of the two drugs. METHODS AND RESULTS Aspirin (325 mg bid) or heparin (5000-U intravenous bolus followed by a perfusion titrated to the APTT) were compared in a double-blind randomized trial ...

Tamoxifen is a selective estrogen receptor modulator (SERM) used for the treatment and prevention of breast cancer. Tamoxifen has been reported to protect against the progression of coronary artery diseases in human and different atherosclerosis animal models by blocking the appearance of the atheromatous plaque. However, the molecular mechanism of this effect remains unknown. Acyl-CoA:choleste...

Abstract Introduction Endometriosis (endo) is a chronic gynecological illness that affects millions of women. Endo has three main symptoms are often the trigger for diagnosis though can only be confirmed through laparoscopy. Laparoscopy surgical procedure allows surgeon to view organs in abdomen and presence endometriosis. The third most common symptom endometriosis after infertility dysmenorrh...