OBJECTIVE To test whether a full moon contributes to motorcycle related deaths. DESIGN Population based, individual level, double control, cross sectional analysis. SETTING Nighttime (4 pm to 8 am), United States. PARTICIPANTS 13 029 motorcycle fatalities throughout the United States, 1975 to 2014 (40 years). MAIN OUTCOME MEASURE Motorcycle fatalities during a full moon. RESULTS 13 02...

Pemphigus Vulgaris (PV) has one of the strongest known HLA disease associations. The majority PV patients studied carry either DRB1*0402 or DQB1*0503. However, studies on associations in have largely focused populations with specific ethnic backgrounds, often Ashkenazi Jewish (AJ) and non-Jewish Caucasians there are limited African descent. We investigated status 11 American (AA) comparison to ...

We previously reported on the impact of melanocortin peptide alpha-melanocyte-stimulating hormone (alpha-MSH) fibroblast function including skin fibrosis. Truncated peptides from C-terminal domain alpha-MSH as well some derivatives have persevered immunomodulating effects but do not bind to melanocortin-1 receptor (MC-1R). Thus, they elicit MC-1R-mediated pigmentation an obligatory adverse effe...

This study explores sociodemographic, clinical, and surgical factors in relation to pain trajectories during the first 3 days following total knee arthroplasty (TKA). 100 patients (mean age 63.5 ± 7.8 years and 93% female) consecutively admitted for uncomplicated primary TKA were prospectively included. Postoperative pain was assessed using pain diaries. Measures of preoperative pain, symptoms,...

Expression of the tetraspanin CO-029 is associated with poor prognosis in patients with gastrointestinal cancer. In a pancreatic tumor line, overexpression of the rat homologue, D6.1A, induces lethally disseminated intravascular coagulation, suggesting D6.1A engagement in angiogenesis. D6.1A-overexpressing tumor cells induce the greatest amount of angiogenesis in vivo, and tumor cells as well a...