Glioblastoma is themost common formof primary brain tumor in adults and is essentially incurable. Despite aggressive treatment regimens centered on radiotherapy, tumor recurrence is inevitable and is thought to be driven by glioblastoma stem-like cells (GSC) that are highly radioresistant. DNA damage response pathways are key determinants of radiosensitivity but the extent to which these overla...

Through photoionization modeling, constraints on the physical conditions of three z ∼ 1.7 singlecloud weak Mg II systems (Wr(2796) ≤ 0.3Å) are derived. Constraints are provided by high resolution R = 45,000, high signal-to-noise spectra of the three quasars HE 0141−3932, HE 0429−4091, and HE 2243−6031 which we have obtained from the European Southern Observatory (ESO) archive of Very Large Tele...

Background: Patent ductus arteriosus (PDA) is common in preterm infants and is associated with significant morbidity. To determine whether the PDA is hemodynamically significant (HSDA), several echocardiographic parameters have been suggested, including retrograde diastolic blood flow in the descending aorta (Dao). Objective: To assess the impact of an HSDA, including retrograde diastolic flow ...

Human Type 2 diabetes is associated with increased incidence of hypertension and disrupted blood pressure (BP) circadian rhythm. Db/db mice have been used extensively as a model of Type 2 diabetes, but their BP is not well characterized. In this study, we used radiotelemetry to define BP and the circadian rhythm in db/db mice. We found that the systolic, diastolic, and mean arterial pressures w...

Introduction: Acute kidney injury (AKI) is a diagnostic emergency threatening patients in a major way. Pediatric renal extra purification methods are limited in African countries due to the nonavailability of resources. Peritoneal dialysis (PD) seems to be the modality that is the most practiced for children with acute renal failure (ARF). Methodology: We conducted a retrospective study on 5 ye...

OBJECTIVE To evaluate efficacy, safety, and tolerability of brexpiprazole adjunctive to antidepressant treatments (ADTs) in patients with major depressive disorder (as defined by DSM-IV-TR criteria) with inadequate response to ADTs. METHOD Patients still depressed despite 1-3 prior ADTs followed by 8 weeks of prospective physician-determined, open-label ADT were randomized (1:1:1) to double-b...

0141-9382/$ see front matter 2010 Elsevier B.V. A doi:10.1016/j.displa.2010.12.002 ⇑ Corresponding author at: University of Provenc PsyCLE Center (E.A. 3273), 29 Avenue Robert Schum France. Tel.: +33 4 42 95 37 40; fax: +33 4 42 95 37 E-mail addresses: Nathalie.Bonnardel@univ-prove [email protected] (A. Piolat), ludovic.le.bigot@u One of the challenges today in human–computer interaction ...