Associated with a chemical reaction network is a natural labelled bipartite multigraph termed an SR graph, and its directed version, the DSR graph. These objects are closely related to Petri nets. The construction of SR and DSR graphs for chemical reaction networks is presented. Conclusions about asymptotic behaviour of the associated dynamical systems which can be drawn easily from the graphs ...

BACKGROUND The phase 3 LUME-Lung 1 study assessed the efficacy and safety of docetaxel plus nintedanib as second-line therapy for non-small-cell lung cancer (NSCLC). METHODS Patients from 211 centres in 27 countries with stage IIIB/IV recurrent NSCLC progressing after first-line chemotherapy, stratified by ECOG performance status, previous bevacizumab treatment, histology, and presence of bra...

This paper presents a short overview of blended learning, showing arguments for and against these concepts. Potential blended learning scenarios are described that vary depending on the degree of instructor involvement, learner self-organisation and on-line moderation or coaching. The paper ends with an example of successful application of a blended learning concept in industry. Definition of B...

We, NMFS, have completed comprehensive status reviews under the Endangered Species Act (ESA) of five species of sawfishes in response to a petition to list six sawfish species. In our 90-day finding we determined that Pristis pristis, as described in the petition, was not a valid species and began our status review on the remaining five species (Anoxypristis cuspidata; Pristis clavata; Pristis ...

Biology is well suited for mathematical description, from the perfect geometry of viruses, to equations that describe the flux of ions across cellular membranes, to computationally intensive models for protein folding. For this short Web review, however, I’m going to focus on how mathematics helps us as biologists sort, evaluate, and draw conclusions about our data. Just as computer technology ...

Never before in history data is generated and collected at such high volumes as it is today. For the exploration of large data sets to be e↵ective, it is important to include the human in the data exploration process and combine the flexibility, creativity, and general knowledge of the human with the enormous storage capacity and the computational power of today’s computers. Visual Analytics he...

Henry Charlton Bastian was born in Truro, Cornwall. He graduated in 1861 at the University College, London, where he worked most of his life. He was one of the first neurologists appointed to the National Hospital, Queen Square. There, he conducted original investigations and pursued wide interests both in medical and biological sciences. He was elected a Fellow of the Royal Society in 1868. In...

UML is by far the most widely used modelling language used nowadays in software engineering, due to its large scope and its wide tool support. This software standard offers many diagrams that cover all typical perspectives for describing and modelling the software systems under consideration. Among those diagrams, UML includes diagrams (activity diagram, state machine diagram, use case diagrams...