BACKGROUND Menopausal hormone therapy to prevent chronic conditions is currently not recommended because of its adverse effects. PURPOSE To update evidence about the effectiveness of hormone therapy in reducing risk for chronic conditions and adverse effects, and to examine whether outcomes vary among women in different subgroups. DATA SOURCES MEDLINE (January 2002 to November 2011), Cochra...

There have been no prior large population-based studies focusing on cutaneous lymphomas (CL) in the United States. Using the Surveillance, Epidemiology and End Results (SEER) program data, we analyzed age-adjusted CL incidence rates (IRs) and survival rates by sex and race/ethnicity. There were 3884 CLs diagnosed during 2001-2005. Cutaneous T-cell lymphomas (CTCLs) accounted for 71% (age-adjust...

Anthropology has striven to adequately understand what human living conditions were like 10000, 20000 or 100 000 years ago. Stone Age (usually divided into the Old Stone or Paleolithic Age, and New Stone or Neolithic Age) extended until some 6000-7000 years ago (Hours, 1982). Agriculture appeared some 10 000 years ago; the first cities some 6000 years ago; the first civilizations about 5000 yea...

Deep-sea and ice-core records show that interglacial periods were overall less “warm” before about 420 000 years ago than after, with relatively higher ice volume and lower greenhouse gases concentration. This is particularly the case for the interglacial Marine Isotope Stage 13 which occurred about 500 000 years ago. However, by contrast, the loess and other proxy records from China suggest an...

John M. Pandolfi* and Jeremy B.C. Jackson Centre for Marine Studies and Department of Earth Sciences, ARC Centre of Excellence for Coral Reef Studies, The University of Queensland, St Lucia, Qld 4072, Australia Center for Marine Biodiversity and Conservation, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093, USA; and Center for Tropical Paleoecology an...