The generation of reactive oxygen species in diabetes is considered to be the major cause for the mutation related defects such as cancer, infertility etc. Glimepiride (Gmp) is a third generation antidiabetic sulphonylurea known to possess the antioxidant effect in streptozotocin (STZ) induced diabetes. In this study, the anti-mutagenic activity of Gmp (0.175, 17.5 and 175 mg/kg, po daily for 4...

Abstract Objectives Aside from the activity of gaseous transmitter molecule nitric oxide (NO) and cyclic GMP producing enzyme soluble guanylyl cyclase (sGC) in human penile erectile tissue, intracellular receptor proteins activated by binding have been considered to play a significant role erection process. In animal models, down-regulation GMP-dependent/binding protein kinase I (cGKI) has link...

Kasus keracunan makanan akibat olahan industri jasa boga merupakan kasus terbanyak kedua setelah rumah tangga. Rumah Sakit golongan B. Keamanan pangan di harus diperhatikan karena melayani pasien yang rentan terkena infeksi bakteri patogen. Kontaminasi pada dapat memperpanjang proses perawatan dan meningkatkan keparahan penyakit Pengelola memiliki pengetahuan baik terhadap manajemen sistem keam...

GMP reductase was purified 150,000-fold from human erythrocytes by affinity chromatography on Cibacron blue/agarose. The enzyme was stable to storage and could be assayed spectrophotometrically. Plots of the velocity-* uersus [GMP]-’ demonstrated downward curvature above 250 pM GMP. GTP was found to be a nonessential activator. It caused the K’, for GMP to decrease from 7.5 to 4.4 pM and the V&...

UNLABELLED The nucleotide-based second messenger bis-(3'-5')-cyclic dimeric GMP (c-di-GMP) is involved in regulating a plethora of processes in bacteria that are typically associated with lifestyle changes. Myxococcus xanthus undergoes major lifestyle changes in response to nutrient availability, with the formation of spreading colonies in the presence of nutrients and spore-filled fruiting bod...

The GNU Multiple Precision Arithmetic Library (GMP) is a widely used library for computing with arbitrary precision arithmetic. has functionally complete bindings many programming languages, including .NET, C++, OCaml, Python, Ruby, and Rust, the notable exception of Java. JGMP provides Java wrappers using GMP from within any JVM-based language. been thoroughly tested benchmarked.

The bacterial second messenger c-di-GMP controls bacterial biofilm formation, motility, cell cycle progression, development and virulence. It is synthesized by diguanylate cyclases (with GGDEF domains), degraded by specific phosphodiesterases (PDEs, with EAL of HD-GYP domains) and sensed by a wide variety of c-di-GMP-binding effectors that control diverse targets. c-di-GMP-binding effectors can...

Genetic and environmental factors that affect the formation of glutenin macropolymer (GMP) particles were investigated by growing Lance 5C 10, Lance 2C12, Warigal 5C10 and Warigal 2C12 lines under widely differing temperature regimes in greenhouse conditions. The GMP characteristics and mixing properties of flour extracted from mature wheat kernels were systematically studied. The amount of GMP...

Stimuli of prostacyclin (PGI2) biosynthesis such as thrombin, bradykinin, histamine, and A23187 increase guanosine 3',5'-cyclic monophosphate (cyclic GMP) levels in primary monolayer cultures of human umbilical vein endothelium by about twofold. This effect is dependent on the presence of extracellular Ca2+. Increases of about tenfold are observed when cyclic GMP phosphodiesterase activity is i...

We report the discovery of spiral-like structure in Hubble Space Telescope images of two dwarf galaxies (GMP 3292 and GMP 3629) belonging to the Coma cluster. GMP 3629 is the faintest such galaxy detected in a cluster environment, and it is the first such galaxy observed in the dense Coma cluster. The large bulge and the faintness of the broad spiral-like pattern in GMP 3629 suggests that its d...