1359-6349/$ see front matter Copyright 2013 ECCO – the European CanCer Organisation. All rights reserved. http://dx.doi.org/10.1016/j.ejcsup.2013.07.054 * Corresponding author: Address: Department of Obstetrics and Gynaecology, University Medical Centre Groningen, Un Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands. Tel.: +31 503 613005; fax: +31 503 611694. E-mail address: a.g.j....

Immunisation with outer membranes of Francisella tularensis induced an efficient protection in guinea pigs against challenge with the virulent strains 503 or 144/713 (type B biovar holarctica), both clinical isolates, and prevented the development of typical signs of infection in hamadryads (baboons), challenged with the virulent strain Schu (type A, biovar tularensis) of F. tularensis. Immunis...

MicroRNAs (miRNAs) directly regulate gene expression at a post-transcriptional level and represent an attractive therapeutic target for a wide range of diseases. Here, we report a novel strategy for delivering miRNAs to endothelial cells (ECs) to regulate angiogenesis, using polymer functionalized carbon nanotubes (CNTs). CNTs were coated with two different polymers, polyethyleneimine (PEI) or ...

*Corresponding author: Christina Flaxel, Professor of Ophthalmology, Casey Eye Institute at Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR 97239, Tel: 503-418-3351; Fax: 503-4947233; E-mail: [email protected] Citation: Patel P, Flaxel C (2015) Visual and Anatomic Outcomes in Eyes with Idiopathic Juxtafoveal Macular Telangiectasia (MacTel) and Full Thickness Macular Ho...

tors N Eng. J Med. 291:503 (1974), it is noted that a "minimum effective concentration" of analgesic drugs must be reached in order for the drug to be therapeutically effective (Danhof, Tr. 17060-61; RX 250-Koch-Weser, p. 503). 548. Failure of an aspirin tablet to reach the threshold or minimum effective concentration in the bloodstream would result in that tablet providing no therapeutic relie...

0168-1699/$ see front matter Published by Elsevier B.V. http://dx.doi.org/10.1016/j.compag.2013.05.002 ⇑ Corresponding author. Tel.: +39 2 503 16566; fax: +39 2 503 16553. E-mail addresses: [email protected] (M. Baietto), letiziapozzi@ fastwebnet.it (L. Pozzi), [email protected] (A.D. Wilson), [email protected] (D. Bassi). 1 Present address: Demetra Società Cooperativa Sociale Onl...

Oncoretroviral vectors encoding either full-length Ag or a corresponding immunodominant peptide were expressed in Langerhans-type dendritic cells (LCs) differentiated from CD34(+) progenitors. We used human CMV as a model Ag restricted by HLA-A*0201 to define parameters for eventual expression of cancer Ags by LCs for active immunization against tumors. Stimulation by CMVpp65(495-503)-pulsed LC...