Convergence of inputs from extrinsic cardiac nerves [vagus and cardiopulmonary (CPN)] on intrinsic cardiac neurons was investigated in the pig ( Sus scrofa). A segment of the right atrial wall containing epicardial neurons along with attached stumps of the right vagus nerve and CPN was maintained in vitro; intracellular recordings were made from 57 neurons. Three types of neuron were identified...

Distributed automation system (DAS) architecture gathers all the hardware and software automation components in order to realize control and monitoring tasks for factory process. To submit and commercially secure an architecture offer, system integrators must assess the performances of a wide range of candidate architectures, which enforce functional requirements. Among many available methodolo...

This paper presents the Backward reachability which is a structural analysis method applicable to Colored Petri Nets (CPN). This method avoids the fastidious computation of simulation and the combinatorial explosion of reachable state space. The backward reachability provides the information about different ways of reaching a particular CPN marking. This evaluation considers the evolution of ma...

This paper reports on the main results from an industrial cooperation project. The project is a joint project between Nokia Research Centre and the CPN group at the University of Aarhus. The purpose of the project was to investigate features and feature interactions in development of Nokia mobile phones through construction of a Coloured Petri Nets (CPN) model. The model is extended with domain...

The contribution of this paper is to propose and justify two general rules that can help to argue the costeffectiveness of use of the formal modelling language Coloured Petri Nets (CPN): (1) Construction of CPN models should be explicitly based on high-quality documentation that software developers already produce; (2) Use of CPN models should be explicitly seen as prototyping. Rule (1) enables...

Carboxypeptidase N (CPN) is a plasma zinc metalloprotease, which consists of two enzymatically active small subunits (CPN1) and two large subunits (CPN2) that protect the protein from degradation. Historically, CPN has been implicated as a major regulator of inflammation by its enzymatic cleavage of functionally important arginine and lysine amino acids from potent phlogistic molecules, such as...

This study explored the effects of Chlamydia pneumoniae (Cpn) infection in elderly patients with Coronary Heart Disease (CHD), as well as related treatment strategies. Serum levels of Endothelin-1 (ET-1), Interleukin-6 (IL-6), C-reactive protein, fibrinogen, soluble vascular cell adhesion molecule-1, and cardiac troponin-1 were determined in 81 elderly CHD patients with Cpn infection (group A) ...

Medication errors are recognized as a major cause of patient safety. Physicians, pharmacists, and nurses need to a greater effort to reduce medication and medical errors. However, it is difficult to identify roles and responsibility through medication process and errors has still happened in a hospital. A major problem of medication process is an ambiguity and regulation violation. We propose a...

Layer 5 pyramidal neurons (L5PNs) in the mouse prefrontal cortex respond to serotonin (5-HT) according to their long-distance axonal projections; 5-HT1A (1A) receptors mediate inhibitory responses in corticopontine (CPn) L5PNs, while 5-HT2A (2A) receptors can enhance action potential (AP) output in callosal/commissural (COM) L5PNs, either directly (in "COM-excited" neurons), or following brief ...

RATIONALE Chlamydia pneumoniae (Cpn) infection may play a role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Few data are available comparing persistent and acute infection of this pathogen in the human respiratory tract. OBJECTIVES To study Cpn-induced innate immune responses in lung tissue from patients with COPD and control subjects ex vivo and in vitro. METHODS Cp...