Recent studies have shown that nuclear transcription factor cyclic adenosine monophosphate response element binding protein (CREB) is overexpressed in many different types of cancers. Therefore, CREB has been pursued as a novel cancer therapeutic target. Naphthol AS-E and its closely related derivatives have been shown to inhibit CREB-mediated gene transcription and cancer cell growth. Previous...

Cognitive Biases. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 658 Designer Error. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 659 Systems Approaches to Error. . . . . . . . .. . . . . . .. . . . . .. . .659 Errors and Cognitive Biases-Implications for Design. .659 Human Expertise 659 Descriptive Models. . . . . . . . . . . . . . . . . . ...

Binding is key in multisensory perception. This study investigated the audio-visual (A-V) temporal binding window in 4-, 5-, and 6-year-old children (total N = 120). Children watched a person uttering a syllable whose auditory and visual components were either temporally synchronized or desynchronized by 366, 500, or 666 ms. They were asked whether the voice and face went together (Experiment 1...

The existence of a temperature-induced absorption band centred in the region of 666 nm is demonstrated for both membrane-bound and soluble cytochrome oxidase in the frozen state. The 666 nm band is generated solely by an increase in temperature of both fully reduced and mixed valence state cytochrome oxidase in the presence of CO or O2 within the 'pocket' containing the active site; it is not f...

The extent o which the 500-Hz component of a steady-state vowel contributed to its phonemic category was measured by estimating the position of the/I/-/t/phoneme boundary along a first formant (F1) continuum. Shifts in the phoneme boundary were calibrated against hifts produced by physical changes inthe level of the 500-Hz component. When the 500-Hz component was presented contralateral tothe r...

absolute prime: a prime that remains prime for all permutations of its digits. E.g., 199, 919 and 991 are all prime. Goal: definitions balanced with curio info. almost-all-even-digits prime: a prime with all even digits except for one odd right-most digit. E.g., 666 · 10 + 1. almost-equi-pandigital prime: a prime with all digits equal in number, except for one particular digit. E.g., (109876543...