Growth factor receptor bound protein 7 (Grb7) is an adaptor protein with established roles in the progression of both breast and pancreatic cancers. Through its C-terminal SH2 domain, Grb7 binds to phosphorylated tyrosine kinases to promote proliferative and migratory signaling. Here, we investigated the molecular basis for the specificity of a Grb7 SH2-domain targeted peptide inhibitor. We ide...

As a severe chronic metabolic disease and autoimmune disorder, type 1 diabetes (T1D) affects millions of people world-wide. Recent advances in antigen-based immunotherapy have provided a great opportunity for further treating T1D with a high degree of selectivity. It is reported that MHC class II I-A(g7) in the non-obese diabetic (NOD) mouse and human HLA-DQ8 are strongly linked to susceptibili...

Multivalent binding, the simultaneous binding of multiple ligands to multiple receptors, has played a central role in a number of pathological processes, including the attachment of viral, parasitic, mycoplasmal, and bacterial pathogens. These biological activities have been extensively investigated to promote targeting of specific cell types, and biological multivalent inhibitors have yielded ...

This article proposes a multivariate model of inflation with conditionally heteroskedastic common and country-specific components. The model is estimated in one-step via Quasi-Maximum Likelihood for the G7 countries for the period Q1-1960 to Q4-2009. It is found that various model specifications considered fit well the first and second order dynamics of inflation in the G7. The estimated volati...

First, we find that stock markets in Latin America, Eastern Europe and the Middle East, and Emerging Asia are sensitive to stock market activity of the G7 countries. However, the impact of the former on the G7 countries is much weaker at different time scales. In the same vein, the North America stock markets help to explain the evolution of returns in Latin America, Emerging Asia, the Far East...

Let C be a smooth complete algebraic curve of genus g and C2g−2 ⊂ Pg−1 the canonical model. It is generally difficult to describe its equations for higher genus. We restrict ourselves to the case of genus 8. If C has no g7, then C14 ⊂ P7 is a transversal linear section [G(2, 6) ⊂ P14] ∩H1 ∩ · · · ∩H7 of the 8-dimensional Grassmannian ([Muk2]). This is the case 〈8 〉 of the flowchart below. In th...

This paper examines the issue of state contingency in interest rate linkages across the G7 economies by employing Kalman (1960,1963) filter techniques to estimate time varying parameter models of bilateral dependence. Our results show that there is convincing evidence that international linkages in interest rates vary considerably over time. There are periods when international interest rate mo...