A New Alkaloid named Sracosalgnenone [ (20S) -20(dimethylamino) -3β-tigoloyl-pregn-5, 16-diene-4-one] was isolated from sarcococca saligna and its structure was established on the basis of spectroscopic techniques includingH, C-NMR and inverse 2D-NMR techniques (DEPT, HMQC and HMBC) UV, MS etc.

P Aksoy-Sagirli, T Yilmaz-Ozden, N Ozsoy, B Ozbek Celik, S Kultur & G Melikoglu Department of Biochemistry, Faculty of Pharmacy, Istanbul University, 34116 Istanbul, Turkey; Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul University, 34116 Istanbul, Turkey; Department of Pharmaceutical Botany, Faculty of Pharmacy, Istanbul University, 34116 Istanbul, Turkey; Department ...

Host shifts of phytophagous insect specialists to novel plants can result in divergent ecological adaptation, generating reproductive isolation and potentially new species. Rhagoletis pomonella fruit flies in eastern North America underwent a host shift ~160 ya from native downy hawthorn (Crataegus mollis) to introduced, domesticated apple (Malus domestica). Divergent selection on diapause phen...

The human polyomaviruses BK (BKPyV) and JC (JCPyV) are ubiquitous pathogens long associated with severe disease in immunocompromised individuals. BKPyV causes polyomavirus-associated nephropathy and hemorrhagic cystitis, whereas JCPyV is the causative agent of the fatal demyelinating disease progressive multifocal leukoencephalopathy. No effective therapies targeting these viruses are currently...

Cardiovascular diseases (CVDs) are still the principal cause of death worldwide. Weakened endothelial function followed by inflammation of the vessel wall hints at atheroscle-rotic lesion formation that causes myocardial infarction and stroke. Heart failure can arise as consequence of large myocardial infarctions. In its more severe stages, heart failure patients have a life anticipation that i...

Four new species of opiine Braconidae are described from Mexico. These are Diachasmimorpha martinalujai Wharton reared from Rhagoletis infesting fruits of Crataegus spp., Diachasmimorpha norrbomi Wharton reared from Euphranta mexicana infesting fruits of Ribes pringlei, Eurytenes (Stigmatopoea) norrbomi Wharton reared from Trypeta concolor mining leaves of Barkleyanthus salicifolia and Eurytene...