The progression of glioblastoma (GBM) is driven by dynamic alterations in the activity and connectivity of gene pathways. Revealing these dynamic events is necessary in order to understand the pathological mechanisms of, and develop effective treatments for, GBM. The present study aimed to investigate dynamic alterations in pathway activity and connectivity across radiotherapy and chemoradiatio...

A multiresolution technique for biomedical image interpolation is presented in this paper. It is an extension of the work on Directional Coherence Interpolation (DCI) [15] – a novel gray-level image interpolation method that interpolates the missing image data along the smoothed Maximum Coherence Directions (MCDs). We propose to apply a pyramidal search strategy for MCD estimation. This coarse-...

A mobile ad hoc network is a collection of wireless mobile nodes forming a temporary network without the support of any established infrastructure or centralised administration. Mobile ad hoc networks face a lot of challenges for designing a scalable routing protocol due to their natural characteristics. The IDea of virtual backbone routing has been proposed for efficient routing in mobile ad h...

Neurodevelopmental insults leading to malformations of cortical development (MCD) are a common cause of psychiatric disorders, learning impairments and epilepsy. In the methylazoxymethanol (MAM) model of MCDs, animals have impairments in spatial cognition that, remarkably, are improved by post-weaning environmental enrichment (EE). To establish how EE impacts network-level mechanisms of spatial...

Wireless Sensor Networks (WSNs) are now widely used for monitoring and controlling of systems where human intervention is not desirable or possible. Connected Dominating Sets (CDSs) based topology control in WSNs is one kind of hierarchical method to ensure sufficient coverage while reducing redundant connections in a relatively crowded network. Moreover, Minimum-sized Connected Dominating Set ...

BACKGROUND AND PURPOSE Patients with epilepsy and malformations of cortical development (MCDs) are at high risk for language and other cognitive impairment. Specific impairments, however, are not well correlated with the extent and locale of dysplastic cortex; such findings highlight the relevance of aberrant cortico-cortical interactions, or connectivity, to the clinical phenotype. The goal of...

Understanding the dynamic changes in connectivity of molecular pathways is important for determining disease prognosis. Thus, the current study used an inference of multiple differential modules (iMDM) algorithm to identify the connectivity changes of sub‑network to predict the progression of osteosarcoma (OS) based on the microarray data of OS at four Huvos grades. Initially, multiple differen...