BackgroundCleft lip and cleft palate (also, known as or facial clefts), are amongst the most common congenital deformities affecting the jaw and face as well as the most common defects associated with lip and palate. Thus, the current study was an attempt to investigate the prevalence and risk factors of or facial clefts in Iranian children.Materials and Methods:The present study, was conducted...

In a search for genetic differences in susceptibility to cleft palate, congenic and recombinant inbred strains of mice were treated with 6-aminonicotinamide or control injections. Of six loci tested, only the chromosome segment marked by N-acetyl transferase was found to affect susceptibility to 6-aminonicotinamide-induced cleft palate. This chromosome segment is known to affect glucocorticoid-...

a 39-year-old pregnant woman at 38 weeks of gestation was referred with labor pain to a hospital. she had consanguinity with her husband. a female newborn had multiple craniofacial anomalies and phocomelia in right upper limb. the disease locus was assigned to chromosome17q21. four days later, infant died of cardiopulmonary arrest.

nasoalveolar molding represents a paradigm shift from traditional presurgical orthopedics in the care of cleft lip and palate patients which has been applied increasingly in the past two decades. this article is a review of recent literature apropos of objectives, appliances, complications and short and long term effects of this technique.

Ultrasound examination of the fetal palate is known to be problematic. The difficulties identified include shadowing by facial bones, its curved anatomy, and its location deep inside the fetal head especially for the posterior part of palate. The soft tissues in the area, e.g. the fetal tongue, also make it more difficult to delineate the palate. Antenatal detection rate of fetal cleft palate h...

Cleft palate is a common birth defect in humans and is a common phenotype associated with syndromic mutations in fibroblast growth factor receptor 2 (Fgfr2). Cleft palate occurred in nearly all mice homozygous for the Crouzon syndrome mutation C342Y in the mesenchymal splice form of Fgfr2. Mutant embryos showed delayed palate elevation, stage-specific biphasic changes in palate mesenchymal prol...

Static palatography has been widely used to investigate consonant articulation. The method is based on the observation of the tongue print (a black paste is spread on the tongue before the production) either directly onto the palate (direct palatography) or onto a pseudo palate (indirect palatography). This study has two main objectives. The first one is to provide an automatic analysis of the ...

Oral focal mucinosis (OFM); It is a rare soft tissue lesion of unknown etiology. was first described by Tomich in 1974. usually occurs as localized, asymptomatic pedunculated or sessile growth on the gingiva hard palate. In intraoral examination 14-year-old systemically healthy female patient who applied to our clinic with complaint gingival enlargement maxillary palate region, well-circumscrib...

Van der Woude syndrome or lip pits is a rare genetic autosomal dominant affection that represents the first cause of syndromic cleft and palate. Lower associated not with palate characteristic in this syndrome. The treatment surgical can be very challenging since aesthetic good results hard to achieve We report familial case as only manifestation.

Transcriptional cofactors are essential to the regulation of transforming growth factor beta (TGFbeta) superfamily signaling and play critical and widespread roles during embryonic development, including craniofacial development. We describe the cleft secondary palate 1 (csp1) N-ethyl-N-nitrosourea-induced mouse model of non-syndromic cleft palate (NSCP) that is caused by an intronic Prdm16 spl...