We have previously reported that both transferred microglia and microglia-conditioned medium (MCM) potentiated the N-methyl-D-aspatate (NMDA) receptor-mediated synaptic responses in cortical neurons. To elucidate the mechanism underlying the potentiation of NMDA receptor-mediated responses by microglia, we examined the effects of MCM on NMDA-induced inward currents in mechanically dissociated h...

MCM-48 and SBA-1 samples were characterized using powder X-ray diffraction and nitrogen adsorption in a wide range of relative pressures. X-ray diffraction provided direct evidence for the high degree of pore structure ordering for the materials under study. Nitrogen adsorption showed that highly ordered MCM-48 materials exhibited sharp steps of capillary condensation and narrow pore size distr...

INTRODUCTION Smokers with posttraumatic stress disorder (PTSD) smoke at higher prevalence rates and are more likely to relapse early in a quit attempt. Innovative methods are needed to enhance quit rates, particularly in the early quit period. Web-based contingency-management (CM) approaches have been found helpful in reducing smoking among other difficult-to-treat smoker populations but are li...

Multiple constant multiplication (MCM) scheme is widely used for implementing transposed direct-form FIR filters. While the research focus of MCM has been on more effective common subexpression elimination, the optimization of addertrees, which sum up the computed sub-expressions for each coefficient, is largely omitted. In this paper, we have identified the resource minimization problem in the...

A zirconium modified MCM-48 mesoporous material was synthesized by surfactant-templated method. Surface grafting Zr-MCM-48 with tungstophosphoric acid led to a great enhancement of both the number of the Brønsted acid sites and acidity strength in comparison with the bare support. At 100 ̊C, the 30 wt% H3PW12O40/Zr-MCM-48 contained 174 mol/g Brønsted acid sites which were 21.7 times greater tha...

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The Mini-Chromosome Maintenance (MCM) proteins are candidates of replicative DNA helicase in eukarya and archaea. Here we report a 2.8 A crystal structure of the N-terminal domain (residues 1-268) of the Sulfolobus solfataricus MCM (Sso MCM) protein. The structure reveals single-hexameric ring-like architecture, at variance from the protein of Methanothermobacter thermoautotrophicus (Mth). More...

We have built and tested a mixed signal Multi-Chip Module (MCM) to be used in the Pre-Processor of the ATLAS Level-1 Calorimeter Trigger. The MCM performs high speed digital signal processing on four analogue trigger input signals. Results are transmitted serially at a serial data rate of 800 MBd. Nine chips of different technologies are mounted on a four layer copper substrate. Analogue-to-dig...

UNLABELLED Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest forms of cancer and is very difficult to treat with conventional chemotherapeutic regimens. Gemcitabine and 5-fluorouracil are used in the management of PDAC and act by indirectly blocking replicative forks. However, these drugs are not highly effective at suppressing disease progression, indicating a need for the develo...

DNA replication origins strikingly differ between eukaryotic species and cell types. Origins are localized and can be highly efficient in budding yeast, are randomly located in early fly and frog embryos, which do not transcribe their genomes, and are clustered in broad (10-100 kb) non-transcribed zones, frequently abutting transcribed genes, in mammalian cells. Nonetheless, in all cases, origi...