نتایج جستجو برای: ژن stk11

تعداد نتایج: 16599  

Journal: :Journal of Immunology 2023

Abstract γδ T cells have been demonstrated to both promote tumor growth/metastasis and efficiently kill cells. This dual role of has attributed their ability produce either IL-17 (γδT17) or IFNγ (γδT1), the former being associated with progression latter anti-tumor activity. cell function is influenced by multiple factors, including recognition stress-induced ligands, as well cytokines chemokin...

Journal: :World journal of gastrointestinal endoscopy 2013
Hiroyuki Yajima Hajime Isomoto Hiroaki Nishioka Naoyuki Yamaguchi Ken Ohnita Tatsuki Ichikawa Fuminao Takeshima Saburo Shikuwa Masahiro Ito Kazuhiko Nakao Kazuhiro Tsukamoto Shigeru Kohno

AIM To explore mutations in serine/threonine kinase 11 (STK11) gene in Peutz-Jeghers syndrome (PJS) with gastrointestinal (GI) hamartomatous polyps. METHODS Six Japanese PJS patients in 3 families were enrolled in this study. Each of the cases had hamartomatous polyposis in the gastrointestinal tract, including the small intestine, along with mucocutaneous hyperpigmentation. Narrow-band imagi...

2017
Myeong Sun Jang Yoo Min Lee Bong Min Ko Goeun Kang Jong-Won Kim Yong Hee Hong

Myeong Sun Jang, M.D., Yoo Min Lee, M.D., Bong Min Ko, M.D., Goeun Kang, M.D., Jong-Won Kim, M.D., and Yong Hee Hong, M.D. Department of Pediatrics and Digestive Disease Center and Research Institute, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon; Department of Laboratory Medicine, Mokpo Hankook Hospital, Mokpo; Department of Laboratory Medicine and Clin...

Journal: :Acta biochimica et biophysica Sinica 2009
Dahua Fan Chao Ma Haitao Zhang

Germline mutations of the LKB1 tumor suppressor gene result in Peutz-Jeghers syndrome (PJS) characterized by intestinal hamartomas and increased incidence of epithelial cancers. Inactivating mutations in LKB1 have also been found in certain sporadic human cancers and with particularly high frequency in lung cancer. LKB1 has now been demonstrated to play a crucial role in pulmonary tumorigenesis...

2013
Marouan Zarrouk Julia Rolf Doreen Ann Cantrell

The present study has examined the role of the serine/threonine kinase LKB1 in the survival and differentiation of CD4/8 double positive thymocytes. LKB1-null DPs can respond to signals from the mature α/β T-cell-antigen receptor and initiate positive selection. However, in the absence of LKB1, thymocytes fail to mature to conventional single positive cells causing severe lymphopenia in the per...

Journal: :Journal of pediatric hematology/oncology 2013
Michael F Wangler Rishikesh Chavan M John Hicks Jed G Nuchtern Madhuri Hegde Sharon E Plon Patrick A Thompson

Peutz-Jeghers syndrome (PJS) is an autosomal dominant cancer predisposition syndrome characterized by melanotic macules and hamartomatous polyps. Small-bowel surveillance in the pediatric PJS population is not designed to identify small-bowel malignancy, which is thought to arise in adulthood. A 13-year-old boy presented with lead-point intussusception, requiring emergent surgical resection. A ...

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