Background: Though the incidence of colorectal carcinoma (CRC) is relatively uncommon in Nigeria, compared to the developed countries, recent studies indicate an increasing trend. Our patients often present at an earlier age, which has important implications for the pathogenesis in Nigeria. MLH1, MSH2, MSH6, PMS2 are the commonly mutated MMR genes in descending order of frequency, with PMS1 and...

Introduction : Aberrant expression of CK7/CK20/CDX2 is reported in percentage colorectal carcinomas (CRC). Aim The objective this study was to investigate specific morphological and immunohistochemical characteristics carcinoma with KRAS mutation status microsatellite instability. Materials methods Seventy-one patients CRC examined were included the investigation. Immunohistochemistry performed...


 Background. Epithelial ovarian carcinomas (EOCs) are lethal female genital tract malignancies with high-grade serous, low-grade endometrioid, clear cell, mucinous and malignant Brenner subtypes. The lifetime risk for developing carcinoma (OC) is 15% in females who have mismatch repair deficiency (MMR-d). MMR-d associated Lynch syndrome, a cancer predisposition condition. Patients may ben...

BACKGROUND Multigene panels can be a cost- and time-effective alternative to sequentially testing multiple genes, especially with a mixed family cancer phenotype. However, moving beyond our single-gene testing paradigm has unveiled many new challenges to the clinician. The purpose of this article is to familiarize the reader with some of the challenges, as well as potential opportunities, of ex...

We have studied the meiotic non-Mendelian segregation (NMS) pattern of seven large heterologous combinations located in the b2 ascospore gene of Ascobolus. The NMS patterns of these aberration heterozygotes widely differ from each other and from those of point mutations located in the same genetic region. They give lower gene conversion frequencies than point mutations, no postmeiotic segregati...