Introduction: The POU class 1 homeobox 1 transcription factor (POU1F1, also known as Pit-1) is expressed in the mammary gland and its overexpression induces profound phenotypic changes in proteins involved in cell proliferation, apoptosis, and invasion. Patients with breast cancer and elevated expression of Pit-1 show a positive correlation with the occurrence of distant metastasis. In this stu...

this study was carried out on olive trees cv. amygdalifolia, to investigate the effect of spraying potassium nitrate, kno3, and zinc sulfate, znso4, on the fruit weight, dimension and volume. the plants were sprayed with 0, 0.5, 1.0 and 1.5% kno3 and 0, 0.25, 0.50 and 0.75% znso4 and their combinations in august about halfway through the fruit growth period. the highest fruit weight was observe...

In open-pit mine planning, the design of the most profitable ultimate pit limit is a prerequisite to developing a feasible mining sequence. Currently, the design of an ultimate pit is achieved through a computer program in most mining companies. The extraction of minerals in open mining methods needs a lot of capital investment, which may take several decades. Before the extraction, the p...

Planning and design procedure of an open pit mining project just can be started after ultimate pit determination. In the carried out study in this paper it was shown that the most important factor in ultimate pit determination and in consequence in the whole planning and design procedure of an open pit mine is the metal price. Metal price fluctuations in recent years were exaggerated and impose...

OBJECTIVE Radioimmunotherapy (RIT) has proven effective for patients with relapsed and refractory lymphoma. However, new types of therapy are strongly desired as B-cell lymphoma remains incurable for many patients. Photoimmunotherapy (PIT) is an emerging targeted cancer therapy that uses photosensitizer (IR700)-conjugated monoclonal antibodies (mAbs) to specifically kill cancer cells. To evalua...

Pituitary protein transcription factor (Pit-1) is a member of a large family of protein transcription factors that include Pit-1, Oct-1, Oct-2, and Unc-86. The goal of this experiment was to determine whether the population of Pit-1-containing cells changes in the anterior pituitary of chicken by the regulation of feeding. White Leghorn hens were subjected to withdrawal and resumption of feedin...

The transcription factor Pit-1/GHF-1 plays an important role in regulating the prolactin (Prl) and growth hormone (GH) genes in mammals. In this study, the role that Pit-1 plays in regulating the prolactin and growth hormone genes in avian species was examined by cotransfection assays and immunofluorescence staining of pituitary sections. In cotransfection assays, turkey Pit-1 activated the tur...

Activation of the human growth hormone (hGH-N) gene in pituitary somatotropes is mediated by a locus control region (LCR). This LCR is composed of DNase I-hypersensitive sites (HS) located -14.5 kb to -32 kb relative to the hGH-N promoter. HSI, at -14.5 kb, is the dominant determinant of hGH-N expression and is essential for establishment of a 32-kb domain of histone acetylation that encompasse...

Vascular calcification is associated with cardiovascular morbidity and mortality. Hyperphosphatemia is an important contributor to vascular calcification. Our previous studies demonstrated that elevated phosphate induces calcification of smooth muscle cells (SMC) in vitro. Inhibition of phosphate transport by phosphonoformic acid blocked phosphate-induced calcification, implicating sodium-depen...