نتایج جستجو برای: ژن oct4

تعداد نتایج: 18435  

2014
HAI LIN LI-HUA SUN WEI HAN TIE-YING HE XIN-JIAN XU KUN CHENG CHENG GENG LI-DAN SU HAO WEN XI-YAN WANG QI-LONG CHEN

Octamer‑binding transcription factor 4 (OCT4) is one of the factors associated with self‑renewal and differentiation in cancer stem cells, and is crucial for the progression of various types of human malignancy. However, the expression and function of OCT4 in human pancreatic cancer has not been fully elucidated. The purpose of the present study was to investigate the function and molecular mec...

2015
Sami Ventelä Eleonora Sittig Leni Mannermaa Juho-Antti Mäkelä Jarmo Kulmala Eliisa Löyttyniemi Leena Strauss Olli Cárpen Jorma Toppari Reidar Grénman Jukka Westermarck

Radiotherapy is a mainstay for treatment of many human cancer types, including head and neck squamous cell carcinoma (HNSCC). Thereby, it is clinically very relevant to understand the mechanisms determining radioresistance. Here, we identify CIP2A as an Oct4 target gene and provide evidence that they co-operate in radioresistance. Oct4 positively regulates CIP2A expression both in testicular ca...

2015
Yoshiki Kaneko Yusuke Suenaga S M Rafiqul Islam Daisuke Matsumoto Yohko Nakamura Miki Ohira Sana Yokoi Akira Nakagawara

Neuroblastoma is a pediatric solid tumor that originates from embryonic neural crest cells. The MYCN gene locus is frequently amplified in unfavorable neuroblastomas, and the gene product promotes the progression of neuroblastomas. However, the molecular mechanisms by which MYCN amplification contributes to stem cell-like states of neuroblastoma remain elusive. In this study, we show that MYCN ...

Journal: :Cancer research 2010
Shih-Hwa Chiou Mong-Lien Wang Yu-Ting Chou Chi-Jen Chen Chun-Fu Hong Wang-Ju Hsieh Hsin-Tzu Chang Ying-Shan Chen Tzu-Wei Lin Han-Sui Hsu Cheng-Wen Wu

Epithelial-mesenchymal transition (EMT), a critical process of cancer invasion and metastasis, is associated with stemness property of cancer cells. Though Oct4 and Nanog are homebox transcription factors essential to the self-renewal of stem cells and are expressed in several cancers, the role of Oct4/Nanog signaling in tumorigenesis is still elusive. Here microarray and quantitative real-time...

Journal: :Development 2003
Alex Bortvin Kevin Eggan Helen Skaletsky Hidenori Akutsu Deborah L Berry Ryuzo Yanagimachi David C Page Rudolf Jaenisch

The majority of cloned animals derived by nuclear transfer from somatic cell nuclei develop to the blastocyst stage but die after implantation. Mouse embryos that lack an Oct4 gene, which plays an essential role in control of developmental pluripotency, develop to the blastocyst stage and also die after implantation, because they lack pluripotent embryonic cells. Based on this similarity, we po...

2014
Ulf Tiemann Adele Gabriele Marthaler Kenjiro Adachi Guangming Wu Gerrit Ulf Lennart Fischedick Marcos Jesús Araúzo-Bravo Hans Robert Schöler Natalia Tapia

Differentiated cells can be reprogrammed into induced pluripotent stem cells (iPSCs) after overexpressing four transcription factors, of which Oct4 is essential. To elucidate the role of Oct4 during reprogramming, we investigated the immediate transcriptional response to inducible Oct4 overexpression in various somatic murine cell types using microarray analysis. By downregulating somatic-speci...

2009
Jung Hwan Kim Min Ki Jee So Young Lee Tae Hee Han Bong Sun Kim Kyung Sun Kang Soo Kyung Kang

BACKGROUND To clarify the role of the POU domain transcription factor Oct4 in Adipose Tissue Stromal Cells (ATSCs), we investigated the regulation of Oct4 expression and other embryonic genes in fully differentiated cells, in addition to identifying expression at the gene and protein levels. The ATSCs and several immature cells were routinely expressing Oct4 protein before and after differentia...

2015
Chao Liu Dijuan Zhang Yuxian Shen Xiaofang Tao Lihua Liu Yongwang Zhong Shengyun Fang

DPF2, also named ubi-d4/requiem (REQU), interacts with a protein complex containing OCT4. This paper provides data in support of the research article entitled "DPF2 regulates OCT4 protein level and nuclear distribution". The highlights include: (1) Denature-immunoprecipitation assay revealed ubiquitination of OCT4 in pluripotent H9 cells, which was enhancedby MG132, a proteasome inhibitor. (2) ...

Journal: :Human reproduction 2010
M Ono T Kajitani H Uchida T Arase H Oda S Nishikawa-Uchida H Masuda T Nagashima Y Yoshimura T Maruyama

BACKGROUND The transcription factor, octamer-binding transcription factor 4 (OCT4)/POU5F1, is expressed in embryonic stem cells, germ cells and some types of adult stem cells. Human OCT4 encodes two isoforms, OCT4A and OCT4B. While OCT4A plays a crucial role in the maintenance of stem cell properties, including pluripotency, whereas OCT4B does not. We previously reported that human myometrium c...

ژورنال: :مجله علوم اعصاب شفای خاتم 0
الهه برفی elahe barfi department of anatomical sciences, school of medical sciences, tarbiat modares university, tehran, iranگروه علوم تشریح، دانشکده پزشکی، دانشگاه تربیت مدرس، تهران، ایران تقی طریحی taghi tirraihi shefa neuroscience research center, khatam-al-anbia hospital, tehran, iran.مرکز تحقیقات علوم اعصاب شفا، بیمارستان خاتم الانبیاء، تهران، ایران شهرام دارابی shahram darabi qazvin university of medical science, school of medicine, qazvin, iran.دانشکده پزشکی، دانشگاه علوم پزشکی قزوین، قزوین، ایران

مقدمه: سلول های بنیادی مشتق از بافت چربی قادرند به سلول های عصبی و گلیالی تمایز یابند. یکی از روش هایی که به واسطه آن می توان تعداد قابل توجهی سلول بنیادی/پیش ساز عصبی از تمایز سلول های بنیادی مشتق از بافت چربی به دست آورد روش کشت نوروسفر می باشد. در این فرایند سلول های بنیادی مشتق از بافت چربی تحت شرایط مناسب تکثیر یافته و تجمعات سلولی تمایز نیافته چند توانی به نام نوروسفر را ایجاد می کنند که ...

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