-The relationships between DNA damage from UV radiation, alkylating drugs and the methylated xanthines (MX) have been studied in normal and malignant rodent and human cells. A comparison of the level of DNA excision repair (repair replication and unscheduled DNA synthesis) confirms that some forms of alkylatingagent damage (probably mono-filar DNA adducts) are less completely removed by both no...

BACKGROUND AND PURPOSE In patients with subarachnoid hemorrhage, the assessment of cerebral autoregulation aids in prognosis as well as detection of vasospasm. Mx is a validated index of cerebral autoregulation based on measures of cerebral perfusion pressure and mean flow velocity on transcranial Doppler but is impractical for longer-term monitoring. Near-infrared spectroscopy is noninvasive a...

We study the constraints that high-redshift structure formation in the universe places on warm dark matter (WDM) dominated cosmological models. We modify the extended Press-Schechter formalism to derive the halo mass function in WDM models. We show that our predictions agree with recent numerical simulations at low redshift over the halo masses of interest. Applying our model to galaxy formatio...

Abstract The identification of protein crystals naturally occurring inside cells and organisms has opened a window for new type macromolecular crystallography (MX) structural biology, referred to as in vivo MX. In the past decade, there have been efforts obtain deeper insights into yet uncontrollable events dictating crystal growth, by further developing sample handling delivery procedures appl...

This paper studies the problem of characterizing the simplest aperiodic discrete point sets, using invariants based on topological dynamics. A Delone set of finite type is a Delone set X such that X −X is locally finite. Such sets are characterized by their patch-counting function NX(T ) of radius T being finite for all T . We formulate conjectures relating slow growth of the patch-counting fun...

The Mx protein is one of the best-characterized interferon-stimulated antiviral mediators. Mx homologs have been identified in most vertebrates examined; however, their location within the cell, their level of activity, and the viruses they inhibit vary widely. Recent studies have demonstrated multiple Mx alleles in chickens and some reports have suggested a specific variant (S631N) within exon...

The present study aims at evaluating the risk of Mutagen X (MX) (3-chloro-4-(dichloromethyl)-5-hydroxy-2 (5H)-furanone) and adverse health effects, associated with direct ingestion of chlorinated drinking water in west of Tehran, supplied by chlorinated drinking water from surface and underground water sources. For one year, MX concentrations in tap water samples has been measured for consumers...

Mx proteins are interferon-induced large GTPases with antiviral activities. They inhibit a wide range of viruses by blocking early stages of the replication cycles. Importantly, Mx GTPases also suppress the growth of highly pathogenic influenza A viruses, such as currently circulating H5N1 viruses or the pandemic H1N1 virus strain of 1918. In this paper, the authors review the properties of Mx ...

Fanconi anemia complementation group-F (FANCF) is a key factor to maintain the function of FA/BRCA, a DNA-damage response pathway. However, the functional role of FANCF in breast cancer has not been elucidated. In this study, we examined the effects and mechanisms of FANCF-RNAi on the sensitivity of breast cancer cells to mitoxantrone (MX). FANCF silencing by FANCF-shRNA blocked functions of FA...