نتایج جستجو برای: ژن homer 1a

تعداد نتایج: 48605  

Journal: :Neuron 2016
Céline Ruegsegger David M. Stucki Silvio Steiner Nico Angliker Julika Radecke Eva Keller Benoît Zuber Markus A. Rüegg Smita Saxena

Spinocerebellar ataxia type 1 (SCA1), due to the expansion of a polyglutamine repeat within the ubiquitously expressed Ataxin-1 protein, leads to the premature degeneration of Purkinje cells (PCs), the cause of which is poorly understood. Here, we identified the unique proteomic signature of Sca1(154Q/2Q) PCs at an early stage of disease, highlighting extensive alterations in proteins associate...

2012
Nirinjini Naidoo Megan Ferber Raymond J. Galante Blake McShane Jia Hua Hu John Zimmerman Greg Maislin Jacqui Cater Abraham Wyner Paul Worley Allan I. Pack

Sleep is an evolutionarily conserved process that is linked to diurnal cycles and normal daytime wakefulness. Healthy sleep and wakefulness are integral to a healthy lifestyle; this occurs when an organism is able to maintain long bouts of both sleep and wake. Homer proteins, which function as adaptors for group 1 metabotropic glutamate receptors, have been implicated in genetic studies of slee...

1965
A. S. Neill

2013
Cheng-Yung Lin Jie-Shin Chen Moo-Rung Loo Chung-Ching Hsiao Wen-Yen Chang Huai-Jen Tsai

A microRNA, termed miR-In300 or miR-3906, suppresses the transcription of myf5 through silencing dickkopf-related protein 3 (dkk3r/dkk3a) during early development when myf5 is highly transcribed, but not at late stages when myf5 transcription is reduced. Moreover, after 24 hpf, when muscle cells are starting to differentiate, Dkk3a could not be detected in muscle tissue at 20 hpf. To explain th...

2016
Christopher Schmehil Andrey Leonov Suzanne M Greydanus-Rutgers Donald E Greydanus

Christopher Schmehil1, Andrey Leonov1, Suzanne M Greydanus-Rutgers2 and Donald E Greydanus1* 1Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, Michigan 2Department of Labor and Delivery, Bronson Methodist Hospital, Kalamazoo, Michigan USA *Corresponding author: Donald E Greydanus, MD, Dr HC (ATHENS), 1Western Michigan University Homer Stryker MD School of Medicine, Ka...

2013
Ilona Obara Scott P. Goulding Adam T. Gould Kevin D. Lominac Jia-Hua Hu Ping Wu Zhang Georg von Jonquieres Marlin Dehoff Bo Xiao Peter H. Seeburg Paul F. Worley Matthias Klugmann Karen K. Szumlinski

Pain alters opioid reinforcement, presumably via neuroadaptations within ascending pain pathways interacting with the limbic system. Nerve injury increases expression of glutamate receptors and their associated Homer scaffolding proteins throughout the pain processing pathway. Homer proteins, and their associated glutamate receptors, regulate behavioral sensitivity to various addictive drugs. T...

2014
Pawel Burkhardt Mads Grønborg Kent McDonald Tara Sulur Qi Wang Nicole King

Reconstructing the evolution and ancestral functions of synaptic proteins promises to shed light on how neurons first evolved. The postsynaptic density (PSD) protein Homer scaffolds membrane receptors and regulates Ca(2+) signaling in diverse metazoan cell types (including neurons and muscle cells), yet its ancestry and core functions are poorly understood. We find that the protein domain organ...

Journal: :Biochemical Society transactions 2003
K Rezvani M Mee S Dawson J McIlhinney J Fujita R J Mayer

The six regulatory non-redundant ATPases in the base of the 19 S regulator of the 26 S proteasome belong to the AAA superfamily of ATPases. Yeast two-hybrid genetic screens, biochemical analyses and cell biological studies have identified and characterized new interactors of the human S6 (rpt3) and S8 (rpt6) ATPases of the 19 S regulator of the 26 S proteasome. The S6 ATPase interacts with gank...

Journal: :The Classical Review 1912

Journal: :Emerita 1986

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