Sperm motility is one of the three fundamental tenets of semen analysis providing diagnostic and prognostic information for both natural and assisted reproduction technology (ART) conception. The landmark papers of John MacLeod and Ruth Gold demonstrated clear differences between subfertile and fertile men in sperm motility (MacLeod and Gold, 1951) which have been confirmed by a plethora of sub...

CatSper family proteins are putative ion channels expressed exclusively in membranes of the sperm flagellum and required for male fertility. Here, we show that mouse CatSper1 is essential for depolarization-evoked Ca2+ entry and for hyperactivated movement, a key flagellar function. CatSper1 is not needed for other developmental landmarks, including regional distributions of CaV1.2, CaV2.2, and...