Epithelial-mesenchymal transition (EMT) is a process by which cancer cells acquire mesenchymal properties, such as induction of vimentin, while epithelial-associated genes like E-cadherin are lost. This enables cells to be more metastatic. Factors that are able to induce EMT include growth factors such as transforming growth factor-β (TGF-β) and epidermal growth factor, and transcription factor...

introduction: the functional effects of orexin-b on the calcium spikes and excitability of the neuronal soma membrane of garden snail, helix aspersa were studied. methods: conventional intracellular recording, under the current clamp conditions was performed to examine the effects of orexin-b on the configuration and electrophysiological properties of calcium spikes. results: application of ore...

Identifying impacts of exotic species on native populations is central to ecology and conservation. Although the effects of exotic predators on native prey have received much attention, the role of exotic prey on native predators is poorly understood. Determining if native predators actively prefer invasive prey over native prey has implications for interpreting invasion impacts, identifying th...

PURPOSE Carcinoma progression is linked to a partially dedifferentiated epithelial cell phenotype. As previously suggested, this regulation could involve transcription factors, Snail and Slug, known to promote epithelial-mesenchymal transitions during development. Here, we investigate the role of Snail and Slug in human breast cancer progression. EXPERIMENTAL DESIGN We analyzed Snail, Slug, a...

Biological changes in Snail-overexpressed SGC7901 cells were studied by establishing a pEGFP-C1-Snail carrier. The significance of Snail in epithelial-mesenchymal transition (EMT) as well as the invasion and metastatic capacity of gastric cancer cells was also discussed; moreover, we attempted to verify the probable cancer stem cell characteristics of Snail-overexpressed cells. A pEGFP-C1-Snail...

Schistosomiasis is a major healthy problem in China, which is one of most badly suffered four countries in the world, and Schistosoma japonicum infection is prevalent in China. In addition, the snail is the only intermediate snail host of Schistosoma japonicum. Therefore, elimination of snail is an important measure that controls and eliminates schistosomiasis. In order to find out the distribu...

This paper reports ongoing investigations into the use and role of paper-mail communications in domestic environments. It utilises ethnographically informed data to analyse how paper mail supports various social roles within the home, particularly a division of labour whereby women tend to be largely responsible for what may be called “managing the home”. Implications for the future of paper ma...

BACKGROUND In ovarian cancer (OC) cells, Snail was reported to induce the epithelial-to-mesenchymal transition (EMT), which is a critical step in OC metastasis. At present little is known about controlling Snail expression in OC cells by using specific microRNAs (miRNAs). METHODS We first used a computational target prediction analysis to identify 6 candidate miRNAs that bind to the 3'-untran...

background: trematodes are a diverse group of endoparasites which require molluscan and vertebrate animals as intermediate and definitive hosts in their life cycle. the present study was carried out to determine the diversity and geographic distribution of infection with trematodes’cercariae in the snail lymnaea gedrosiana from north-west iran. methods: a total number of 6759 lymnaeidae snails ...

Understanding how predators respond to fluctuations in prey density has important conservation andmanagement implications, particularly for threatened and endangered specialists. However, directly linking prey densities to predator behavior and demography over broad spatial and temporal scales is rare, in part, because it can be prohibitively expensive and time-consuming to quantify prey densit...