An 86-year-old man with a Binkhorst 2-loop intraocular lens (IOL) that was implanted in the pupillary sphincter 33 years earlier was examined. The pupil of the implanted eye with the Binkhorst IOL was irregular and the eye had pseudoexfoliation (PEX) syndrome. Pupillary erosion resulted from rubbing of the IOL edge against the pupillary sphincter with PEX material. The IOL was removed because o...

Modulation of the balance between pro- and antiangiogenic factors holds great promise for the treatment of a broad spectrum of human disease ranging from ischemic heart disease to cancer. This requires both the identification of angiogenic regulators and their efficient delivery to target organs. Here, we demonstrate the use of a noncatalytic fragment of matrix metalloproteinase 2 (termed PEX) ...

PURPOSE To assess the prevalence of pseudoexfoliation (PEX) and its associations in a population-based setting. DESIGN Population-based, cross-sectional study. METHODS The Central India Eye and Medical Study included 4711 individuals. All study participants underwent a detailed ophthalmological examination. After medical pupil dilation, PEX was assessed by an experienced ophthalmologist usi...

Glioma recurrences develop at the borders of the surgical cavity and are the main cause of their poor prognosis. There are no therapeutic advances to reduce the incidence of recurrence or animal models that closely mimic the clinical scenario to evaluate novel therapeutics. This work investigates the efficacy of endogenous inhibitors, in preventing the recurrence of human malignant gliomas, in ...

PURPOSE To investigate the aqueous humor, lens, and serum concentrations of zinc, iron, and copper in patients with pseudoexfoliative cataract and compare with patients who have senile cataract without pseudoexfoliation. METHODS Twenty-five patients with pseudoexfoliative cataract and 25 patients with senile cataract as control group were enrolled in the study. Samples from aqueous humor, ser...

Quinine is the most common cause of Drug induced thrombotic microangiopathy (DITMA), being the offending drug in 33% of cases. We present a case of DITMA after only a single dose of quinine with no previous history of quinine exposure treated successfully with plasma exchange (PEX), oral corticosteroid followed by mycophenolatemofetil (MMF). The diagnosis was made by the close temporal relation...

BACKGROUND Plasma exchange (PEX) is a life-saving therapeutic procedure in patients with thrombotic thrombocytopaenic purpura (TTP) and other thrombotic microangiopathic anaemias (TMAs). However, it may be associated with significant complications, exacerbating the morbidity and mortality in this patient group. STUDY DESIGN AND METHODS We reviewed all PEX procedures over a 72-month period, fo...

The aim is to present the phacoemulsification phaco-chop technique in a patient with pseudoexfoliation (PEX) syndrome without the use of additional pupil dilatation methods. Phacoemulsification surgery and posterior chamber intraocular lens implantation in patients with PEX syndrome is associated with a higher rate of intraoperative complications such as zonular dehiscence, capsular rupture, vi...

Introduction: Recently, first examples of inner-volume-imaging and motion artifact suppression based on Parallel EXcitation (PEX) have been presented [1]. However, in most PEX based applications, 3D selectivity has been achieved by 2D spatially selective excitation combined with perpendicular 1D slice selective refocusing. Therefore, the necessity of multi pulse sequences and the limitation to ...

BACKGROUND Pulmonary exacerbations (PEx), frequently associated with airway infection and inflammation, are the leading cause of morbidity in cystic fibrosis (CF). Molecular microbiologic approaches detect complex microbiota from CF airway samples taken during PEx. The relationship between airway microbiota, inflammation, and lung function during CF PEx is not well understood. OBJECTIVE To de...