PURPOSE/OBJECTIVES To measure differences in cyclosporine A (CSA) trough concentrations from blood collected as a peripheral sample and from a CSA-uncontaminated (naive) lumen of a double-lumen central line. DESIGN Prospective, comparative study. SETTING Pediatric university teaching hospital in metropolitan Australia. SAMPLE 71 paired central and peripheral CSA blood samples from a conve...

BACKGROUND Prediction of cyclosporine (CSA) efficacy and toxicity in individual patients is difficult. There is no practical, biologically relevant, pharmacodynamic measure of CSA effect. A major effect of CSA is to decrease interleukin-2 (IL-2) production; however, measurement of this effect in isolated lymphocytes as a marker of response to CSA has been problematic. METHODS CSA inhibition o...

Background: Cyclosporine A (CsA) is an immunosuppressant with therapeutic indications in various immunological diseases; however, its use is associated with chronic nephropathy. Oxidative stress has a crucial role in CsA-induced nephrotoxicity. The present study evaluates the protective effect of edaravone on CsA-induced chronic nephropathy and investigates its antioxidant and nitric oxide modu...

OBJECTIVES This study aimed to explore factors relating to intention to participate in community child sexual abuse (CSA) prevention programs among Chinese adults in Hong Kong. METHOD A total of 1,606 Chinese adults (497 men and 1,109 women) were individually interviewed about their intention to participate in community CSA prevention programs, endorsement of myths about CSA, their acquaintan...

In vitro studies have demonstrated that cyclosporine A (CsA) acts by inhibiting the phosphatase activity of calcineurin, an important mediator of T-cell activation. The relationship of CsA administration in vivo, calcineurin activity, and graft-versus-host disease (GVHD) has yet to be studied. The calcineurin activities of mononuclear cells isolated from 62 bone marrow transplant recipients and...

Clarithromycin (CLM) has been known to increase the cyclosporine (CsA) trough level in human and feline organ transplant patients. However, the interaction of CLM with CsA has not been reported in dogs. In this study, the effects of multiple dosing of CLM on the pharmacokinetics of CsA in three healthy beagles were investigated. The treatments included CsA 10 mg/kg alone and CsA 10 mg/kg + mult...

Cyclosporin A (CSA) suppresses immune function by blocking the cyclophilin A and calcineurin/NFAT signaling pathways. In addition to immunosuppression, CSA has also been shown to have a wide range of effects in the cardiovascular system including disruption of heart valve development, smooth muscle cell proliferation, and angiogenesis inhibition. Circumstantial evidence has suggested that CSA m...

Volume 125 Published by Foundation of Computer Science (FCS), NY, USA Indexed with Google Scholar, CiteSeer and CSA Technology Research Database, ProQuest Volume 124 Published by Foundation of Computer Science (FCS), NY, USA Indexed with Google Scholar, CiteSeer and CSA Technology Research Database, ProQuest Volume 123 Published by Foundation of Computer Science (FCS), NY, USA Indexed with Go...

Volume 126 Published by Foundation of Computer Science (FCS), NY, USA Indexed with Google Scholar, CiteSeer and CSA Technology Research Database, ProQuest Volume 125 Published by Foundation of Computer Science (FCS), NY, USA Indexed with Google Scholar, CiteSeer and CSA Technology Research Database, ProQuest Volume 124 Published by Foundation of Computer Science (FCS), NY, USA Indexed with Go...

A competitive protein-binding assay for cyclosporine based on use of the intracellular cyclosporine-binding protein cyclophilin (CYP) was used to measure cyclosporin A (CsA) and its bioactive metabolites in whole blood. CYP from cytoplasmic extracts or erythrocyte lysates was applied in the binding assay with use of [3H]CsA as tracer and charcoal adsorption for separating bound from free tracer...