Background: In addition to Human Leukocyte Antigens (HLA) compatibility, gene polymorphisms in cytokines might also be important in the quality of allogeneic immune response. Objective: To evaluate the influence of HLA-DR matching and a number of cytokine gene polymorphisms on acute rejection after living-unrelated donor (LURD) kidney transplantation. Methods: A total of 42 renal transplants pe...

Minor histocompatibility antigens (MiHAs) are polymorphic peptides on the cell surface derived from self-proteins that capable to induce an immune response during allogeneic hematopoietic stem cells transplantation. Their presentation occurs in context of certain major complex (HLA – human leucocyte antigen) alleles. One most common HLA alleles is HLA-A*02:01. Accordingly, for a significant num...

testing revealed that the patient was positive for HLA-DRB1*04, HLA-DRB1*12, HLA-DQB1*03, andHLA-DQB1*04. To best of our knowledge, this is first case fulminant T1DM reported to occurimmediately after COVID-19 infection.

Abstract Activation of CD8 +T cells against pathogens and cancers involves the recognition antigenic peptides presented in complex with human leukocyte antigen (HLA) class-I proteins. Peptide binding to HLA-I proteins is coordinated by a multi-protein called peptide loading (PLC). Tapasin, key PLC component, facilitates optimization peptides. However, different allotypes have variable requireme...

Recently, we have shown that HLA-A*02:01 and HLA-A*24:02 in de novo metastatic prostate cancer (MPCa) an important role disease progression. Since MPCa represents a small group among patients diagnosed with (PCa), it was obvious to try extend the validity of our results larger cohorts PCa patients. Herein, analyzed irrespective their status at diagnosis include, besides MPCa, those localized (L...

conclusions our investigation demonstrated that there is a highly significant association between the studied alleles and t1d. it can be construed that haplotype hla-dr3-dq2 has a very modest effect with respect to the risk of t1d. patients and methods this study was a case-control study. the number of samples was determined using the cochran formula. eighty unrelated t1d patients, including 42...

background: hla-g gene contains 15 alleles including a null allele, hla-g*0105n. previous studies have shown that hla-g*0105n does not encode the complete hla-g1 or hla-g5 isoforms but encodes a functional hla-g protein with the ability to in-hibit nk cell cytolysis. thus, although the biological functions of hla-g1 and hla-g5 proteins are abrogated, other isoforms such as hla-g2 can replace th...