Thalidomide-based Immunomodulatory Drugs (IMiDs®), including lenalidomide and pomalidomide, are effective therapeutics for multiple myeloma. These agents have been approved with, or are under clinical development with, other targeted therapies including proteasome inhibitors, αCD38 monoclonal antibodies, as well as histone deacetylase (HDAC) inhibitors for combination therapy. HDAC inhibitors b...

In order to understand the bioaccumulation of (241)Am and (134)Cs in scallops living in sediments, the uptake and depuration kinetics of these two elements were investigated in the king scallop Pecten maximus exposed via seawater, food, or sediment under laboratory conditions. Generally, (241)Am accumulation was higher and its retention was stronger than (134)Cs. This was especially obvious whe...

Endoplasmic reticulum (ER) oxidoreductin 1α (Ero1α) is a disulfide producer in the ER of mammalian cells. Besides four catalytic cysteines (Cys(94), Cys(99), Cys(394), Cys(397)), Ero1α harbors four regulatory cysteines (Cys(104), Cys(131), Cys(208), Cys(241)). These cysteines mediate the formation of inhibitory intramolecular disulfide bonds, which adapt the activation state of the enzyme to th...

Reprint Requests: Fousseyni S. Touré, PhD, Centre International de Recherches, Médicales de Franceville, BP 769 Franceville, Gabon, Tel: 00 241 06615636; Fax: 00 241 677095; E-mail: [email protected] Received: November 2, 2005 Revised: January 11, 2006 Accepted: January 18, 2006 Grant Support: State of Gabon, by Total-Fina-Elf and by the French Ministry of Foreign Affairs

Lipoprotein lipase (LPL) plays a central role in normal lipid metabolism as the key enzyme involved in the hydrolysis of triglycerides present in chylomicrons and very low density lipoproteins. LPL is a member of a family of hydrolytic enzymes that include hepatic lipase and pancreatic lipase. Based on primary sequence homology of LPL to pancreatic lipase, Ser-132, Asp-156, and His-241 have bee...

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