Two syntheses of natural viridic acid, an unusual triply N-methylated peptide with two anthranilate units, are presented. The first one is based on peptide-coupling strategies and affords the optically active natural product in 20% overall yield over six steps. A more economical approach with only four steps leads to the similarly active racemate by utilizing a Ugi four-component reaction (Ugi-...

The effect of coherency WC/Co phase boundaries on the fracture toughness of the nanocrystalline WC-Co cemented carbides is studied by MD simulation method. The simulation results show that the nanocrystalline WC-Co cemented carbides with coherency WC/Co phase boundaries has higher fracture toughness than that without coherency WC/Co phase boundaries. Moreover, the mechanism of why coherency WC/...

AIM To compare the maximal power output (MPO) of subjects presenting a central adiposity to those of controls and to study the links between plasma leptin or indices of insulin sensitivity (QUICKI) and physical fitness (PF). METHODS MPO was determined for 169 middle-aged men divided into two groups according to waist circumference (WC- < 94 cm, WC+ ≥ 94 cm) each subdivided in two subgroups wi...

BACKGROUND Body mass index (BMI) and waist circumference (WC) are the most used anthropometric measures to identify obesity. While BMI is considered to be a simple and accurate estimate of general adiposity, WC is an alternative surrogate measure of visceral obesity. However, WC is subject to significant inter-examiner variation. The aim of the present study was to correlate BMI and WC measures...

Fine-grained tungsten carbide copper (WC-Cu) cemented carbide was sintered via spark plasma sintering at 1773K using a fine WC powder with a mean particle size of 0.11 mm. The mechanical properties were compared with tungsten carbide cobalt (WC-Co) cemented carbide and a binderless WC-sintered material. The Vickers hardness and fracture toughness obtained by the indentation fracture method for ...

In the Neurospora circadian negative feedback loop, white collar 1 (WC-1) and WC-2 form the WC complex that activates frequency (frq) transcription. Here we show that Not1 is a WC-interacting protein and is important for maintaining WC levels. The not1 transcript displays a circadian oscillation with a similar phase as frq. Down-regulation of not1 leads to low levels of WC-1 and WC-2 and a dela...

Denitrifying bioreactors can be effective for removing nitrate from agricultural tile drainage; however, questions about cold springtime performance persist. The objective of this study was to improve the nitrate removal rate (NRR) of denitrifying bioreactors at warm and cold temperatures using agriculturally derived media rather than wood chips (WC). Corn ( L.) cobs (CC), corn stover (CS), bar...

This study aimed to examine differences in CVD risk factors across four crosstabulated groups according to health-related physical fitness index (PFI, composite index of standing long jump, 50-m test, and 800or 1000-m run/walk) and waist circumference (WC) in Guangzhou youth. Participants comprised 588 males and 579 females aged 11–18 years from Guangzhou, China. They were cross-tabulated into ...