نتایج جستجو برای: نظریه منبع محور rbv
تعداد نتایج: 69073 فیلتر نتایج به سال:
BACKGROUND About one third of patients infected with human immunodeficiency virus (HIV) also have chronic hepatitis due to hepatitis C virus (HCV). HCV therapy with simeprevir, pegylated interferon alfa (PegIFNα) and ribavirin (RBV) have been shown to be superior to PegIFNα + RBV alone in non-HIV patients, but no randomized trials in patients with HCV genotype 1 (HCV-1)/HIV coinfection are avai...
BACKGROUND In Italy, anti-HCV drugs are provided free of charge by the National Health System. Since 2011, three drug regimens including a directly acting antiviral (DAA) are considered the gold standard for HCV treatment. However, these drugs add a significant cost (roughly €26,000) to the combination of pegylated-interferon-α/ribavirin (PEG-IFN/RBV), which before DAA represented the unique tr...
سازمان ها علی رغم سرمایه گذاری های سرسام آور سخت افزاری و نرم افزاری که برای استقرار مدیریت دانش انجام داده اند به نتیجه مورد انتظارشان دست نیافته اند. تحقیق حاضر تلاشی است برای پاسخگویی به این سؤال بنیادین که سازمان با تکیه بر چه رویکردی می تواند به مزیت رقابتی مبتنی بر منابع کلیدی خود دست یابد؟ و به عبارتی مسیر بلوغ سازمان در بهره برداری از دانش خود چیست و سازمان روی چه فرآیندهایی سرمایه گذار...
BACKGROUND Hepatitis C virus (HCV) infection usually results in long-term viremia. Entry of HCV into the hepatocyte requires claudin-1, -6, -9 and occludin. The efficacy of Pegylated interferon-α (PEG-IFN) treatment against HCV infection increased when ribavirin (RBV) was added to the therapeutic scheme. Our aim was to investigate if PEG-IFN plus RBV regulate claudin expression. MATERIAL AND ...
Combined pegylated interferon (PEG-IFN)+ribavirin (RBV) therapy has been used as a primary treatment for chronic hepatitis C. However, IFN-induced autoimmune disease, including type 1 diabetes mellitus, has been highlighted as one of the problems with this therapy. Here we report the case of a patient who developed type 1 diabetes mellitus during combined PEG-IFN+RBV therapy for hepatitis C but...
aim : the objective of this study was to evaluate the real outcomes of chronic hepatitis c patients, who treated with interferon plus ribavirin (inf-rbv) and peg-interferon plus ribavirin (peg-rbv). background : despite the peg-rbv has become a standard treatment of hepatitis c virus (hcv) around the world; and in iran too, but in developing countries like as iran, inf-rbv is still used among s...
OBJECTIVES To assess the clinical effectiveness and cost-effectiveness of pegylated interferon alpha (PEG) and non-pegylated interferon alpha (IFN) and ribavirin (RBV) for the treatment of adults with histologically mild chronic hepatitis C (HCV) infection. DATA SOURCES Electronic bibliographic databases were searched up to July 2005. REVIEW METHODS A systematic review and an economic evalu...
This study reviews empirical studies of the resource-based view (RBV) and examines methodological issues and new directions that will help to clarify the value and boundaries of the RBV. Through our comprehensive review of the research design and operationalization of resource-based constructs used in 125 empirical studies, we (1) discuss key empirical issues particularly important to RBV resea...
We apply insights from organizational behavior, psychology, and sociology to make the case that community in which a firm is embedded valuable, rare, inimitable, nonsubstitutable resource holds potential as source of sustained competitive advantage. First, we review several key principles resource-based view (RBV) show how they strategic resource, incorporating prior work simultaneously address...
BACKGROUND This study aimed to define factors associated with relapse among responders to pegylated interferon (PEG-IFN) plus ribavirin (RBV) therapy in chronic hepatitis C. METHODS A cohort of genotype 1b chronic hepatitis C patients treated with PEG-IFN plus RBV and who had an undetectable HCV RNA by week 12 (n=951) were randomly assigned to model derivation (n=636) or internal validation (...
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