Immune checkpoint blockades, such as inhibitors against programmed death 1 (PD-1) and its ligand (PD-L1), have received extensive attention in the past decade because of their dramatic clinical outcomes in advanced malignancies. However, both primary and acquired resistance becomes one of the major obstacles, which greatly limits the long-lasting effects and wide application of PD-1/PD-L1 block...

In many diseases such as cancer, simultaneous use of two or more pharmacologically active agents will be more effective and have fewer side effects. In this study a new palladium(II) complex with formula of [Pd(phen)(py-dtc)]NO3 (where is phen 1,10-phenanthroline and py-dtc is n-propyldithiocarbamate), was synthesized. The cytotoxic activity of this complex was tested against leukemia K562 cell...

Palladium nanoparticles supported on multi-walled carbon nanotubes (Pd/MWCNTs) have been synthesized using a modified polyol reduction method and its performance in methanol oxidation reactions has evaluated. The morphology of palladium on MWCNTs was characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The catalytic performance of synthesized catalyst ...

به منظور تولید رادیوایزوتوپ تکنسیم-۹۹ حاصل از واپاشی رادیواکتیو مولیبدن-۹۹ و خالص‌­سازی محصول فرایند انحلال اسیدی هدف مینیاتوری، لازم است آلودگی ید گازی در حد قابل قبولی کاهش یابد. این جاذب‌های جامد استفاده می‌شود. یکی بهترین مورد موردنیت حاوی نقره تشکیل شده است. پژوهش روش سنتز مشخصات جاذب بررسی قرار گرفته برای تهیه بلورهای حفره‌دار با اندازه حدود ۱۰ میکرومتر نسبت آلومینیم سیلیکون برابر 2/5 شد ...

Objective(s):Parkinson's disease (PD) is known for motor impairments. But often, there are non-motor symptoms such as cognitive deficiency and pain misperception, owing to possible role of nigrostriatal pathway. Antioxidants have protective effect on free radical-induced neuronal damage in PD. To further address, we examined the effects of ellagic acid (EA) in a rat model of PD induced by 6-hyd...

Background: The aim of this prospective study was to evaluate the characteristics of patients, treated by acute peritoneal dialysis (PD). We also assessed the indications for PD, PD-associated complications and neonatal outcomes in our patients. Methods: During five years, 30 term newborns underwent temporary cycling PD. The procedure was performed by applying the manual technique. A straight ...