Authors contributed equally to this work.

Antitachycardia pacing (ATP) is a programmable therapy in implantable cardiac defibrillator (ICD) devices that has been demonstrated to effectively reduce the need for shocks. Limited data, however, exists on potential benefits of early ATP delivery ventricular fibrillation (VF) zone. While programmed be delivered as first line tachycardia (VT) events, it does so only once episode meets detecti...

Objective(s): This study intended to investigate the effects of Ginsenoside-Rbl (Gs-Rbl) on fatty acid β-oxidation (FAO) in rat failing heart and to identify potential mechanisms of Gs-Rbl improving heart failure (HF) by FAO pathway dependent on AMP-activated protein kinase (AMPK). Materials and Methods: Rats with chronic HF, induced by adriamycin (Adr), were randomly grouped into 7 groups. Gs-...

The objective of the present study was to investigate the role of nanocarrier of magnetic isotope of 25-Mg2+ (PMC16) in liver toxicity, ATP content and oxidative stress due to malathion (MAL) exposure. PMC16 nanoparticles were administered in different doses (0.05, 0.1 and 0.2 LD50) intravenously (iv) 40 minutes after a single MAL (0.25 LD50= 207 mg/kg) intraperitoneal (ip) injection as a compl...

Abstract Adenosine triphosphate (ATP) is an energy compound present in living organisms and required by cells for performing operations such as replication, molecules transportation, chemical synthesis, etc. ATP connects with through specialized sites called ATP-sites. ATP-sites are various proteins of a cell. The life span cell can be controlled controlling compounds without the provision to c...

We reported previously that the human RNF2 (RING finger protein 2) protein is an E3 ubiquitin ligase that interacts with the human ubiquitin-conjugating enzyme Hip-2/hE2-25K. In the present study, we show that RNF2 interacts with S6' ATPase, a subunit of the proteasomal 19 S regulatory complex. S6' interacts with RNF2 through its N-terminal RING domain, and RNF2 interacts with S6' through its C...

The 26S proteasome degrades polyubiquitinated proteins by an energy-dependent mechanism. Here we define multiple roles for ATP in 26S proteasome function. ATP binding is necessary and sufficient for assembly of 26S proteasome from 20S proteasome and PA700/19S subcomplexes and for proteasome activation. Proteasome assembly and activation may require distinct ATP binding events. The 26S proteasom...