نتایج جستجو برای: مهارکنندههای pim
تعداد نتایج: 2511 فیلتر نتایج به سال:
ATM switches have been proposed as the switching fabric cores of many high-performance IP switches. In this paper, we present an efficient algorithm called IPPIM for scheduling variable-length IP packets on these switches and compare its performance with the original parallel iterative matching (PIM) ATM cell scheduling algorithm. The mean IP packet delays using both the PIM and the IP-PIM sche...
ownload g a cell-based high-throughput screen designed to detect small chemical compounds that inhibit cell h and survival, we identified three structurally related compounds, 21A8, 21H7, and 65D4, with differactivity on cancer versus normal cells. Introduction of structural modifications yielded compound , which inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 ...
RATIONALE Studies in transgenic mice showed the key role of (Pim-1) (proviral integration site for Moloney murine leukemia virus-1) in the control of cardiomyocyte function and viability. OBJECTIVE We investigated whether Pim-1 represents a novel mechanistic target for the cure of diabetic cardiomyopathy, a steadily increasing cause of nonischemic heart failure. METHODS AND RESULTS In strep...
OBJECTIVE To investigate the national prevalence of potentially inappropriate medications (PIMs) prescribed in ambulatory care clinics in Taiwan according to three different sets of regional criteria and the correlates of PIM use. DESIGN Cross-sectional study. SETTING This analysis included older patients who visited ambulatory care clinics in 2009 and represented half of the older populati...
The oncogenic serine/threonine kinase Pim-1 phosphorylates and activates the ATP-binding cassette transporter breast cancer resistance protein (ABCG2). The ABC transporter P-glycoprotein (Pgp; ABCB1) also contains a Pim-1 phosphorylation consensus sequence, and we hypothesized that Pim-1 also regulates Pgp. Pgp is exported from the endoplasmic reticulum (ER) as a 150-kDa species that is glycosy...
Translationally controlled tumor protein (TCTP/TPT1) was identified from a yeast 2-hybrid screen and shown to interact with Pim-3, a member of the proto-oncogene Pim family with serine/threonine kinase activity. TCTP was aberrantly expressed in human pancreatic cancer cells and malignant ductal epithelial cells, but not in normal pancreatic duct epithelial cells adjacent to tumor foci of human ...
The Pim protein kinases play important roles in cancer development and progression, including prostate tumors and hematologic malignancies. To investigate the potential role of these enzymes as anticancer drug targets, we have synthesized novel benzylidene-thiazolidine-2,4-diones that function as potent Pim protein kinase inhibitors. With IC(50) values in the nanomolar range, these compounds bl...
Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) is frequently detected in acute myeloid leukemia (AML) patients and is associated with a dismal long-term prognosis. FLT3 tyrosine kinase inhibitors provide short-term disease control, but relapse invariably occurs within months. Pim protein kinases are oncogenic FLT3-ITD targets expressed in AML cells. We show that increased Pim...
Personal Information management (PIM) is a research area that receives interest from a variety of disciplines including human-computer interaction, information retrieval, information systems research and psychology to mention but a few. The diversity in approaches and the cross-disciplinary nature of PIM have resulted in a fragmented picture of the problems and challenges designers of PIM tools...
Each Protocol Independent Multicast Sparse Mode (PIM-SM) router in a PIM domain that supports Any Source Multicast (ASM) maintains Group-to-RP mappings that are used to identify a Rendezvous Point (RP) for a specific multicast group. PIM-SM has defined an algorithm to choose a RP from the Group-to-RP mappings learned using various mechanisms. This algorithm does not consider the PIM mode and th...
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