It is hypothesized that Ca2+ stimulation of calmodulin (CaM)-activated adenylyl cyclases (AC1 or AC8) generates cAMP signals critical for late phase LTP (L-LTP) and long-term memory (LTM). However, mice lacking either AC1 or AC8 exhibit normal L-LTP and LTM. Here, we report that mice lacking both enzymes (DKO) do not exhibit L-LTP or LTM. To determine if these defects are due to a loss of cAMP ...

Amphetamines have been used as cognitive enhancers to promote learning and memory. Amphetamines are also drugs of abuse that may promote the initiation of strong memories that ultimately lead to addiction. To understand how methamphetamine (Meth) may be augmenting learning and memory, we chose a relatively simple system, the pond snail, Lymnaea stagnalis. We studied the effects of Meth exposure...

1Renuka A Bradoo, 2Rahul R Modi, 3Anagha A Joshi, 4Vikas Wahane 1Professor and Head, Department of Otolaryngology, Head and Neck Surgery, LTM Medical College and General Hospital Mumbai, Maharashtra, India 2Assistant Professor, Department of Otolaryngology, Head and Neck Surgery, LTM Medical College and General Hospital Mumbai, Maharashtra, India 3Associate Professor, Department of Otolaryngolo...

“Làng thông minh – Xã Kết Nối” (LTM XKN) là một mô hình chuyển đổi số ở khu vực nông thôn với cấp tác động làng, xã kết hợp các thành phần cấu của Nông mới (NTM). Giai đoạn 2021 2025, Chính phủ đặt ra mục tiêu chương trình NTM phải gia tăng về lượng và chất qua ban hành quyết định điều chỉnh, bổ sung chí NTM, nâng cao, kiểu mẫu. Trong đó đề chỉ hướng lồng ghép vào chí. Trên cơ sở tham khảo đánh...

Recent findings indicate that regions in the medial temporal lobe (MTL) do not only play a crucial role in long-term memory (LTM) encoding, but contribute to working memory (WM) as well. However, very few studies investigated the interaction between these processes so far. In a new functional magnetic resonance imaging paradigm comprising both a complex WM task and an LTM recognition task, we f...

One of the intriguing questions in neurobiology is how long-term memory (LTM) traces are established and maintained in the brain. Memory can be divided into at least two temporally and mechanistically distinct forms. Short-term memory (STM) lasts no longer than several hours, while LTM persists for days or longer. A crucial step in the generation of LTM is consolidation, a process in which STM ...

Much prior research has shown that retrieval of information from long-term memory (LTM) can influence many aspects of complex cognition in situ. However, research also has shown that not all individuals manage information retrieved from LTM in equivalent fashions. Specifically, high working memory capacity (WMC) individuals have been shown to be better able to manage not only what information i...

The induction of gene expression has been correlated with long-lasting neuronal plasticity and long-term memory (LTM) formation. The fast activation of constitutive transcription factors by signaling mechanisms is thought to be the link between synaptic events and gene expression. However, only one constitutive transcription factor, CREB, has been shown to play a key role in several memory para...

This paper proposes a model for the short-term memory (STM) of unique lists of known items, as, for instance, a phone number. We show that the ability to accurately store such lists in STM depends strongly on interaction with the preexisting long-term memory (LTM) for individual items (e.g., digits). We have examined this interaction in computer simulations of a network based on physiologically...

Results from neuroimaging studies have shown that the dorsolateral prefrontal cortex (DLPFC) implements processes critical for organizing items in working memory (WM). Based on its role in WM, we hypothesized that the DLPFC should contribute to long-term memory (LTM) formation by strengthening associations among items that are organized in WM. We conducted an event-related functional magnetic r...