Laser Capture Microdissection (LCM) is a powerful tool to isolate and study gene expression pattern of desired and less accessible cells or tissues from a heterogeneous population. Existing LCM-based methods fail to obtain high quality RNA including small RNAs from small microdissected plant tissue and therefore, are not suitable for miRNA expression studies. Here, we describe an efficient and ...

Cerebrospinal fluid (CSF) and sera from 129 patients of a study population of 139 were tested for antibody to herpes simplex, measles,and mumps viruses. Herpes simplex virus antibody was found in three of five patients with laboratory-confirmed herpes simplex infection and in eight patients without serological or virological evidence of current infection with this or other common neurotropic vi...

INTRODUCTION Alterations in voltage-gated sodium channel (VGSC) function have been linked to chronic pain and are good targets for analgesics. Lacosamide (LCM) is a novel anticonvulsant that enhances the slow inactivation state of VGSCs. This conformational state can be induced by repeated neuronal firing and/or under conditions of sustained membrane depolarisation, as is expected for hyperexci...

PURPOSE The goal of this study is to report the efficacy and tolerability of lacosamide (LCM) monotherapy, as first-line and conversion regimens, in the treatment of patients with partial-onset seizures. METHODS We retrospectively reviewed the charts of patients with focal epilepsy on LCM monotherapy from six centers in Spain. Efficacy and tolerability were evaluated in the overall group and ...

In neonatal or congenital lymphocytic choriomeningitis (LCM) virus carrier mice, low numbers of T lymphocytes were always infected, but attempts to infect resting or stimulated T lymphocytes in previously uninfected adult mice have consistently failed. Only T cells in newborn mice were susceptible to LCM virus and their infection persisted when the animals grew older. Infectibility declined wit...

Let e and n be positive integers and S = {x1, . . . , xn} be a set of n distinct positive integers. The n × n matrix having eth power [xi, xj ] of the least common multiple of xi and xj as its (i, j)-entry is called the eth power least common multiple (LCM) matrix on S, denoted by ([S]). The set S is said to be gcd closed (respectively, lcm closed) if (xi, xj) ∈ S (respectively, [xi, xj ] ∈ S) ...

ABSTRACT: 10 Owing to the complexity of neurodegenerative diseases, multiple cellular types need to be targeted 11 simultaneously in order for a given therapy to demonstrate any major effectiveness. Ultrasound12 sensitive coated microbubbles (in a targeted nanoemulsion) are available. Versatile small-molecule 13 drug(s) targeting multiple pathways of Alzheimer's disease pathogenesis are known. ...

Let e and n be positive integers and S = {x1, . . . , xn} be a set of n distinct positive integers. The n × n matrix having eth power [xi, xj ] of the least common multiple of xi and xj as its (i, j)-entry is called the eth power least common multiple (LCM) matrix on S, denoted by ([S]). The set S is said to be gcd closed (respectively, lcm closed) if (xi, xj) ∈ S (respectively, [xi, xj ] ∈ S) ...

introduction there is very limited literature describing the association of lateral condyle mass (lcm) fracture of the distal humerus associated concurrently with olecranon fracture. herein, a case is reported of a displaced lcm fracture with displaced olecranon fracture, due to complex trauma while getting out of a vehicle, which was managed by open reduction and internal fixation. conclusions...