OBJECTIVE We related organ-specific autoantibodies, including diabetes-associated autoantibodies (DAAs) and non-DAAs to systemic cytokines/chemokines in type 1 and type 2 diabetes. RESEARCH DESIGN AND METHODS From the European Action LADA (latent autoimmune diabetes in adults) cohort, patients with adult-onset type 1 diabetes (n = 80, of whom 50 had LADA and 30 had classic type 1 diabetes) an...

Autoimmunity is a well-known pathogenic component in type 1 diabetes (T1DM). The assumption that the pathogenesis of type 2 diabetes (T2DM) also encompasses autoimmune aspects is recognized increasingly, based on the presence of circulating autoantibodies against β cells, self-reactive T cells, but also on the glucose-lowering efficacy of some immunomodulatory therapies in T2DM. The identificat...

<p class="BAB">Penelitian dilakukan untuk menganalisis pengaruh (1) waktu aplikasi Trichoderma terhadap pertumbuhan bibit lada; (2) konsentrasi pupuk organik cair dan (3) interaksi dengan lada. Penelitian dilaksanakan di Kebun Agrowisata Fakultas Pertanian, Universitas Muslim Indonesia Kabupaten Pangkep. berlangsung pada bulan Juli hingga Desember 2021. Rancangan penelitian menggunakan Ac...

Annual Crop Planning (ACP) is an NP-hard-type optimization problem in agricultural planning. It involves finding optimal solutions concerning the seasonal allocations of a limited amount of agricultural land amongst the various competing crops that are required to be grown on it. This study investigates the effectiveness of employing three new local search (LS) metaheuristic techniques in deter...

T ype 2 diabetes is fourto sixfold more common in the South Asian population of the U.K. than in the indigenous white Caucasian population. A subset of all patients initially diagnosed with type 2 diabetes shows evidence of slowly evolving islet autoimmunity, termed latent autoimmune diabetes in adults (LADA). LADA is characterized by the presence of circulating autoantibodies specific for isle...

We present new K-and L ′-band imaging observations for members of the young (3−5 Myr) σ Orionis cluster, obtained with UIST at UKIRT. We determine (K − L ′) colour excesses with respect to the photospheres, finding evidence for warm cir-cumstellar dust around 27 out of 83 cluster members that have masses between 0.04 M ⊙ and 1.0 M ⊙. This indicates a circumstellar disc frequency of at least (33...

OBJECTIVE Secreted frizzled-related protein 5 (sfrp5), like adiponectin, has been identified as a novel insulin-sensitising and anti-inflammatory adipokine. Our objective was to determine whether differences of circulating plasma sfrp5 concentration exist among type 2 diabetes (T2D), latent autoimmune diabetes in adults (LADA) and healthy population. METHODS Enzyme-linked immuno sorbent assay...