BACKGROUND According to current guidelines, new second-generation oral Hi-antihistamines, as well as intranasal corticosteroids (ICSs), are recommended for the treatment of allergic rhinitis (AR) in adults and children. OBJECTIVE To assess changes in AR severity, in addition to nasal symptoms and health-related quality of life (HRQoL), after 4 weeks of treatment with rupatadine in a cohort of...

Persistent androgen receptor (AR) activation drives therapeutic resistance to second-generation AR pathway inhibitors and contributes the progression of advanced prostate cancer. One mechanism is point mutations in ligand binding domain that can transform antagonists into agonists. The F877L mutation, identified patients treated with enzalutamide or apalutamide, confers both apalutamide. Compou...

Friedel-Crafts alkylation of 4-tert-butylaniline with 2 equiv of benzhydrol affords bulky 2,6-bis(diphenylmethyl)-4-tert-butylaniline (Ar*NH2) in good yield, which can be readily synthesized on a tens of grams scale. The reaction of 6 equiv of Ar*NH2 with triphosgene generates the symmetric urea (Ar*NH)2CO, which, upon dehydration with a P2O5/Al2O3 slurry in pyridine, produces the sterically en...

A number of cyclopentadienyltitanium aryloxide complexes, 1-Ar-2,3,4,5-Me(4)-Cp(2,6-(i)Pr(2)C(6)H(3)O)TiCl(2) (Ar = 4-Me(3)SiPhenyl (5), 4-(i)PrPhenyl (6), 4-MePhenyl (7), 3,5-(CF(3))(2)Phenyl (8)) and (1-Ar-2,3,4,5-Me(4)CpTiCl(2))(2)(OAr'O) (Ar' = 4,4'-(3,3',5,5'-(i)Pr(4)C(6)H(2)-C(6)H(2)), Ar = 4-SiMe(3)Phenyl (9), 4-MePhenyl (10)) were synthesized from the reaction of a corresponding cyclope...

Accidental discovery of androgen receptor (AR) expression in high-grade salivary gland cancer led to evaluation of that finding. In this study we evaluated the immunohistochemical expression of AR in a series of 37 formalin-fixed, paraffin-embedded malignant salivary gland tumors using two commercially available antibodies. Nuclear immunoreactivity for AR was demonstrated in 3 of 4 salivary duc...

Several nitrosyl complexes of Fe and Co have been prepared using the sterically hindered Ar-nacnac ligand (Ar-nacnac = anion of [(2,6-diisopropylphenyl)NC(Me)](2)CH). The dinitrosyliron complexes [Fe(NO)(2)(Ar-nacnac)] (1) and (Bu(4)N)[Fe(NO)(2)(Ar-nacnac)] (2) react with [Fe(III)(TPP)Cl] (TPP = tetraphenylporphine dianion) to generate [Fe(II)(NO)(TPP)] and the corresponding mononitrosyliron co...

Because cE−cI > ar gives ∂V (t,0) ∂p > 0, C 0(0) = 0 implies pFB > 0. Now we have shown pFB ∈ (0, 1), which implies (pFB(ar+ cI) + (1− p)cE) ∈ (ar+ cI , cE). Applying the condition a f(t) < ar+ cI , we get ∂V (t,p) ∂t > 0, which implies t > t. ¥ PROOF OF LEMMA 2, 3, 4. We will prove Lemma 2. Proofs of Lemma 3 and 4 are similar and thus omitted. The Kuhn-Tucker condition is −1+prf(t) ≤ 0 with eq...

The terminal phosphorus monoxide complex (OP)Mo(N[(t)Bu]Ar)(3), 1 (Ar = 3,5-Me(2)C(6)H(3)), undergoes an O-for-PSiR(3) metathesis reaction with the niobium phosphinidene complex (i)Pr(3)SiPNb(N[CH(2)(t)Bu]Ar)(3), 2, to generate the oxoniobium complex ONb(N[CH(2)(t)Bu]Ar)(3), 3, and the diphosphenido complex (i)Pr(3)SiPPMo(N[(t)Bu]Ar)(3), 4. The structure of 4, as determined by X-ray crystallogr...

Postcollision-interaction (PCI) effects involving multistep decay processes following Ar $1s$ photoionization has been studied by Auger electron spectroscopy. The experiment focused on $LMM$ electrons measured in small photon energy steps across the threshold. Decay pathways that we include (1) ${\mathrm{Ar}}^{+*}2{p}^{--1}\ensuremath{\rightarrow}{\mathrm{Ar}}^{2+}3{p}^{--2}$ LMM\ensuremath{\al...