Lactoferrin (Lf) is a potential-targeting ligand for hepatocellular carcinoma (HCC) cells because of its specific binding with asialoglycoprotein receptor (ASGPR). In this present work, a doxorubicin (DOX)-loaded, Lf-modified, polyethylene glycol (PEG)ylated liposome (Lf-PLS) system was developed, and its targeting effect and antitumor efficacy to HCC was also explored. The DOX-loaded Lf-PLS sy...

Genomic selection involves computing a prediction equation from the estimated effects of a large number of DNA markers based on a limited number of genotyped animals with phenotypes. The number of observations is much smaller than the number of independent variables, and the challenge is to find methods that perform well in this context. Partial least squares regression (PLS) and sparse PLS wer...

In this paper I review covariance-based Partial Least Squares (PLS) methods, focusing on common features of their respective algorithms and optimization criteria. I then show how these algorithms can be adjusted for use as optimal scaling tools. Three new PLS-type algorithms are proposed for the analysis of one, two or several blocks of variables: the NonMetric NIPALS, the Non-Metric PLS Regres...

Partial least squares (PLS) methods have recently been used for many pattern recognition problems in computer vision. Here, PLS is primarily used as a supervised dimensionality reduction tool to obtain effective feature combinations for better learning. However, application of PLS to large datasets is hindered by its higher computational cost. We propose an approach to accelerate the classical ...

PLS Generalised Linear Regression: foundations and recent advances with variable selection and validation procedures Vincenzo Esposito Vinzi Universita degli Studi di Napoli; [email protected] PLS (Partial Least Squares) univariate regression (PLS1) is a model linking a numerical dependent variable to a set of numerical (or dummy) explanatory variables especially feasible in situa...

BACKGROUND Loss-of-function point mutations in the cathepsin C gene are the underlying genetic event in patients with Papillon-Lefèvre syndrome (PLS). PLS neutrophils lack serine protease activity essential for cathelicidin LL-37 generation from hCAP18 precursor. AIM We hypothesized that a local deficiency of LL-37 in the infected periodontium is mainly responsible for one of the clinical hal...

Near-infrared (NIR) spectrometry will present a more promising tool for quantitative measurement if the robustness and predictive ability of the partial least square (PLS) model are improved. In order to achieve the purpose, we present a new algorithm for simultaneous wavelength selection and outlier detection; at the same time, the problems of background and noise in multivariate calibration a...

Partial least squares (PLS) is sometimes used as an alternative to covariance-based structural equation modeling (SEM). This paper briefly reviews currently available SEM techniques, and provides a critique of the perceived advantages of PLS over covariance-based SEM as commonly cited by PLS users. Specific attention is drawn to the primary disadvantage of PLS, namely the lack of consistency of...