BACKGROUND This study was performed to investigate the effect of microRNA-203 (miR-203) on cell proliferation and migration in triple-negative breast cancer (TNBC). METHODS Real-time PCR was performed to detect the expression of miR-203 in TNBC cell lines. miR-203 precursor and control microRNA (miRNA) were transfected into triple-negative breast cancer (TNBC) cell lines and the effects of mi...

Purpose: The MUC1-C oncoprotein is an intracellular target that is druggable with cell-penetrating peptide inhibitors. However, development of peptidyl drugs for treating cancer has been a challenge because of unfavorable pharmacokinetic parameters and limited cell-penetrating capabilities. Experimental Design: Encapsulation of theMUC1-C inhibitor GO-203 in novel polymeric nanoparticles was stu...

2 BEGRIFFSBESTIMMUNG ................................................................................................... 202 2.1 MODELLBEGRIFF ................................................................................................................ 202 2.2 ASPEKTE DES REFERENZBEGRIFFS...................................................................................... 202 2.2.1 Wiederve...

I . SOURCES AND LEVELS OF RADON EXPOSURES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 203 A . Outdoors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 203 B . Indoors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

OBJECTIVE Evidence supports an important role for miR-203 in the regulation of the proliferation, migration and invasion of prostate cancer (PCa) cells. However, the exact mechanisms of miR-203 in PCa are not entirely clear. METHODS We examined the expression of miR-203 in prostate cancer tissues, adjacent normal tissues, PCa cell lines and normal prostate epithelial cells by qRT-PCR. Then, t...

The aim of this study was to investigate the effect of a eukaryotic expression vector expressing hsa-miR-203 on the sensitivity of K562 leukemia cells to arsenic trioxide (ATO) and the possible mechanism of action. The eukaryotic expression vector expressing the hsa-miR-203 plasmid (PmiR-203) was transfected into K562 cells using Lipofectamine 2000. bcr/abl 3' untranslated region (UTR) and bcr/...

برخی از گونه ‏های زنبور تریکوگراما، دارای نوعی همزیستی با باکتری Wolbachia هستندکه باعث القاء بکرماده ‏زایی در آنها می‏شود. جمعیت‌هایی این پارازیتوئید تخم آفات که نتاج ماده بیشتری تولید می‌کنند، می‌توانند بالقوه توان بالاتری برخوردار باشند. پس شناسایی یک جمعیت بومی آلوده به ولباکیا Trichogramma brassicae، بررسی‏ هایی منظور ارزیابی توانایی‌های تک‏جنسی (A) قیاس جمعیت‌‏های دوجنسی طبیعی (B) و تغذیه...

Gene expression is potently regulated through the action of microRNAs (miRNAs). Here, we present evidence of a miRNA regulating Hakai protein. Hakai was discovered as an E3 ubiquitin-ligase that mediates the posttranslational downregulation of E-cadherin, a major component of adherens junctions in epithelial cells and a potent tumour suppressor. Recent data have provided evidence that Hakai aff...