The essential role of MCM 2-7 proteins in the initiation of DNA replication in all eukaryotes is well known. Their role in replication elongation is supported by numerous studies, but there is still a knowledge gap in this respect. Even though biochemical studies have established an association of MCM proteins with replication forks, previous immunofluorescence studies in mammalian cells have s...

DNA replication and its connection to M phase restraint are studied extensively at the level of single cells but rarely in the context of a developing animal. C. elegans lin-6 mutants lack DNA synthesis in postembryonic somatic cell lineages, while entry into mitosis continues. These mutants grow slowly and either die during larval development or develop into sterile adults. We found that lin-6...

OBJECTIVE To assess the relative risk of major congenital malformation (MCM) from in utero exposure to antiepileptic drug (AEDs). METHODS Prospective data collected by the UK Epilepsy and Pregnancy Register were analysed. The presence of MCMs recorded within the first three months of life was the main outcome measure. RESULTS Full outcome data were collected on 3607 cases. The overall MCM r...

Deregulation of mini-chromosome maintenance (MCM) proteins is associated with genomic instability and cancer. MCM complexes are recruited to replication origins for genome duplication. Paradoxically, MCM proteins are in excess than the number of origins and are associated with chromatin regions away from the origins during G1 and S phases. Here, we report an unusually wide left-handed filament ...

of FPGA and MCM Technology Joel Darnauer, Tsuyoshi Isshiki, Por rio Garay, John Ramirez, Vijayshri Maheshwari, Wayne Wei-Ming Dai Applied Sciences Building, Computer Engineering, UC Santa Cruz, Santa Cruz, CA 95064 Internet: @ce.ucsc.edu Abstract Multichip module technology can be used to dramatically increase the capability and performance of eld programmable gate arrays (FPGAs) and the eld pr...

The Vapnik-Chervonenkis (VC) dimension measures the complexity of a learning machine, and a low VC dimension leads to good generalization. The recently proposed Minimal Complexity Machine (MCM) learns a hyperplane classifier by minimizing an exact bound on the VC dimension. This paper extends the MCM classifier to the fuzzy domain. The use of a fuzzy membership is known to reduce the effect of ...

Introduction In recent years, a master chemical mechanism (MCM) has been developed to describe the atmospheric degradation of VOC in the atmosphere (Jenkin et al., 1997a; Saunders et al., 1997). The MCM has been developed as part of a collaborative project between the University of Leeds, AEA Technology plc and the UK Meteorological Office, and funded by the UK Department of the Environment (no...