•Mutually antagonistic binding of phosphorylated eIF2 and ISRIB to eIF2B•Opposing structural rearrangement eIF2B by or eIF2•Phosphorylated exposes ISRIB’s ability enhance activity in vitro•Weak ISR-inhibitory cells lacking The small molecule antagonizes the activation integrated stress response (ISR) translation initiation factor 2, eIF2(?P). eIF2(?P) bind distinct sites their common target, eI...

Infertility is a core component of the growing recognition sexual and reproductive health as fundamental human right. It acknowledged by key international bodies – including United Nations (UN) World Health Organization (WHO) disease that deserves medical care (United General Assembly 2005United Assembly. Resolution adopted 60/1. 2005 Summit Outcome. Available at:https://www.un.org/en/developme...

The placement of nucleosomes along genomic DNA is determined by signals that can be specific or degenerate at the level of sequence; the latter signals are harder to find using conventional methods. In recent years, the development of sophisticated machine learning techniques that can extract subtle phased signals has improved our ability to distinguish between various classes of nucleosome-pos...

The recently reported metalation/transmetalation route for the synthesis of CCC-bis(NHC) pincer ligand supported transition-metal complexes was extended to Pt. 2-(1,3-Bis(N-butylimidazol-2-ylidene)phenylene)(chloro)platinum(II) (1) and its bromo analogue 2 were synthesized and characterized. X-ray crystal structure determinations revealed complexes 1 and 2 to have distorted-square-planar config...

Ocean Drilling Program (ODP) Leg 199, “The Paleogene Equatorial Transect” (Sites 1215 through 1222), was designed to study the evolution of the equatorial Pacific current and wind system as the Earth went from maximum Cenozoic warmth to initial Antarctic glaciations. The drilling program was primarily devoted to a transect along 56to 57-Ma crust, old enough to capture the Paleocene/ Eocene boun...