In vivo observations of microcirculatory behavior during autoregulation and adaptation to varying myocardial oxygen demand are scarce in the human coronary system. This study assessed microvascular reactions to controlled metabolic and pressure provocation [bicycle exercise and external counterpulsation (ECP)]. In 20 healthy subjects, quantitative myocardial contrast echocardiography and arteri...

ABSTACT OBJECTIVES: Myocardial blood flow (MBF) imaging is used in patients with suspected cardiac sarcoidosis, and also in stress/rest studies. The accuracy of MBF is dependent on imaging parameters such as new reconstruction methodologies. In this work, we aim to assess the impact of a novel PET reconstruction algorithm (Bayesian-penalized likelihood-BPL) on the values determined from the cal...

OBJECTIVE This study aimed to evaluate maximum bite forces (mBF) in dominant (DS) and non-dominant sides (NDS) at certain time periods after the insertion of new complete dentures based on prior experience and gender. MATERIALS AND METHODS A total of 88 patients, complete denture wearers (CDWs), were examined. The maximum bite force at the intercuspal position between the first molars in 3 se...

BACKGROUND Myocardial blood flow (MBF) can be measured with positron emission tomography (PET) and its quantification should provide diagnostic information beyond that obtained through standard visual analysis. However, this possibility has not been fully studied with PET and generator-produced rubidium-82 (⁸²Rb). We evaluated regional MBF in segments with and without ischemia using ⁸²Rb PET in...

The transcription complexes SBF and MBF mediate the G(1)-S transition in the cell cycle of Saccharomyces cerevisiae. In late G(1), SBF and MBF induce a burst of transcription in a number of genes, including G(1)- and S-phase cyclins. Activation of SBF and MBF depends on the G(1) cyclin Cln3 and a largely uncharacterized protein called Bck2. We show here that the induction of SBF/MBF target gene...

OBJECTIVES The purpose of the present study was to evaluate the effect of modified Widman flap (MWF) surgery (as a periodontal treatment procedure) on maximum bite force (MBF; as an indicator of patient function). MATERIALS AND METHODS In this clinical trial, 24 patients were examined for their MBF before and at one, four and eight weeks after their MWF surgery. These recordings along with th...

UNLABELLED Absolute quantitation of myocardial blood flow (MBF) by PET is an established method of analyzing coronary artery disease (CAD) but subject to the various shortcomings of available radiotracers. Flurpiridaz F 18 is a novel PET radiotracer that exhibits properties of an ideal tracer. METHODS A new absolute perfusion quantitation method with flurpiridaz was developed, taking advantag...

In fission yeast cells, Cds1 is the effector kinase of the DNA replication checkpoint. We previously showed that when the DNA replication checkpoint is activated, the repressor Yox1 is phosphorylated and inactivated by Cds1, resulting in activation of MluI-binding factor (MBF)-dependent transcription. This is essential to reinitiate DNA synthesis and for correct G1-to-S transition. Here we show...

Myocardial perfusion MRI is acquired with a T1-weighted dynamic MRI sequence. Fully quantitative analysis of myocardial perfusion MRI allows the absolute quantification of myocardial blood flow (MBF) through the use of complex mathematical modeling. There are essentially two main methods for quantification of absolute MBF: the linear time-invariant model and the compartment model. Maximized con...

Simulations of the influence of contrast agent bolus dispersion on the shape of the contrast agent bolus and on quantification of myocardial blood flow (MBF) have been made using an exponential residue function model, and an computational fluid dynamics (CFD) approach. Based on the exponential residue function model, up to 20% underestimation of MBF appeared reasonable. CFD simulations showed t...