Orphanin FQ/nociceptin (OFQ/N), the endogenous ligand for the orphan receptor-like/kappa(3)-like opioid receptor clone, produces a variety of behavioral responses, including those associated with pronociception and antinociception. The OFQ/N precursor rattus-proOFQ (rppOFQ/N) contains several paired basic amino acids, which raises the possibility that post-translational processing can be respon...

The purpose of this study was to predict a safe starting dose of AMG 181, a human anti-α 4 β 7 antibody for treating inflammatory bowel diseases, based on cynomolgus monkey pharmacokinetic (PK) and pharmacodynamic (PD) data. A two-compartment model with parallel linear and target-mediated drug disposition for AMG 181 PK in cynomolgus monkey was developed. The estimated parameters were allometri...

BACKGROUND Fc epsilon RI plays a central role in atopy, thus genetic variants of Fc epsilon RI-beta may alter receptor function to enhance atopic responses and may manifest as a more severe atopic phenotype and more symptomatic atopic disease. The immunological and clinical features of atopy in children with and without the Leu 181 variant of Fc epsilon RI-beta were compared. METHODS Sixty Br...

OBJECTIVE To evaluate the correlation between perception of dyspnea during a mild to moderate asthma attack using the Modified Borg Scale (MBS) and peak expiratory flow rate (PEFR). METHODS This was a cross-sectional study conducted with children and adolescents who sought a pediatric emergency service due to an asthma attack. Data were collected from July 2005 to June 2006. Demographic data ...

microRNAs (miRNAs) are a class of short noncoding RNA molecules that have a critical role in the initiation and progression of types of human cancer, including prostate cancer. In the present study, the expression of miR-181 in prostate cancer tissues was evaluated and was demonstrated to be significantly upregulated in prostate cancer tissues compared with that in adjacent normal tissues. The ...

1 MIRA project, National Astronomical Observatory of Japan, Mitaka, Tokyo 181-8588, Japan e-mail: [email protected] e-mail: [email protected] 2 Extrasolar Planet Project Office, National Astronomical Observatory of Japan, Mitaka, Tokyo 181-8588, Japan 3 Division of Optical and Infrared Astronomy, National Astronomical Observatory of Japan, Mitaka, Tokyo 181-8588, Japan 4 Max-Planc...

matrix metalloproteinases (mmps) play an important role in gastric cancer (gc). accumulated evidence suggests that functional mmp-1 and mmp-7 gene polymorphisms are associated with several tumors. the aim of this study was to investigate two single nucleotide polymorphisms, mmp-1 -1607 1g/2g and mmp-7 -181 a/g, and their potential relationship with gc. we examined 246 gc  patients and 252 age-a...

ORIGINAL ARTICLES Leprosy and Childhood /. A. Kinnear Brown 173 The Mtoko Quintuplets F. Morley Smith and A. W. Husband 181 Muscle Relaxants in Anaesthesia 5. B a d e r ............................185 The Retroverted Uterus K. Duff ................................. 181 Effects of Certain Diseases on Population M. G e lfa n d ....................... 181 African Leishmaniasis B. K irk ..............

Due to an increase in serious infections and a lack of efficient therapies, Klebsiella pneumoniae has recently gained more recognition. The production carbapenemases is one the most common strategies by which K. acquire resistance carbapenems considered last resort antibiotics. Previously collected isolates from different clinical settings on basis their genetic profile, mainly absence presence...